High-dose DHA has more profound effects on LDL-related features than high-dose EPA: The ComparED study

High-dose DHA has more profound effects on LDL-related features than high-dose EPA: The ComparED... Abstract Context Supplementation with high dose of docosahexaenoic acid (DHA) increases serum LDL-cholesterol (C) concentrations more than high dose eicosapentaenoic acid (EPA). Mechanisms underlying this difference are unknown. Objective To examine the phenotypic change in LDL and mechanisms responsible for the differential LDL-C response to EPA and DHA supplementation in men and women at risk for cardiovascular disease. Design, setting, participants and intervention In a double-blind controlled crossover study, 48 men and 106 women with abdominal obesity and subclinical inflammation were randomized to a sequence of three treatment phases: 1- 2.7 g/d of EPA, 2- 2.7 g/d of DHA, and 3- 3 g/d of corn oil. All supplements were provided as 3x1 g capsules for a total of 3 g/d. The 10-week treatment phases were separated by nine-week washouts. Main outcome measure In vivo kinetics of apolipoprotein (apo) B-100-containing lipoproteins were assessed using primed-constant infusion of deuterated leucine at the end of each treatment in a subset of participants (n=19). Results Compared with EPA, DHA increased LDL-C concentrations (+3.3%, P=0.038) and mean LDL particle size (+0.7 Å, P<0.001) and reduced the proportion of small LDL (-3.2%, P<0.01). Both EPA and DHA decreased proprotein convertase subtilisin/kexin type 9 concentrations similarly (-18.2% vs. -25.0%, P<0.0001 vs. control). Compared with EPA, DHA supplementation increased both LDL apo B-100 fractional catabolic rate (+11.4%, P=0.008) and production rate (+9.4%, P=0.03). Conclusions This study shows for the first time that supplementation with high-dose DHA increases LDL turnover and contributes to larger LDL particles compared with high-dose EPA. Copyright © 2018 Endocrine Society http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Clinical Endocrinology and Metabolism Oxford University Press

High-dose DHA has more profound effects on LDL-related features than high-dose EPA: The ComparED study

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Publisher
Endocrine Society
Copyright
Copyright © 2018 Endocrine Society
ISSN
0021-972X
eISSN
1945-7197
D.O.I.
10.1210/jc.2017-02745
Publisher site
See Article on Publisher Site

Abstract

Abstract Context Supplementation with high dose of docosahexaenoic acid (DHA) increases serum LDL-cholesterol (C) concentrations more than high dose eicosapentaenoic acid (EPA). Mechanisms underlying this difference are unknown. Objective To examine the phenotypic change in LDL and mechanisms responsible for the differential LDL-C response to EPA and DHA supplementation in men and women at risk for cardiovascular disease. Design, setting, participants and intervention In a double-blind controlled crossover study, 48 men and 106 women with abdominal obesity and subclinical inflammation were randomized to a sequence of three treatment phases: 1- 2.7 g/d of EPA, 2- 2.7 g/d of DHA, and 3- 3 g/d of corn oil. All supplements were provided as 3x1 g capsules for a total of 3 g/d. The 10-week treatment phases were separated by nine-week washouts. Main outcome measure In vivo kinetics of apolipoprotein (apo) B-100-containing lipoproteins were assessed using primed-constant infusion of deuterated leucine at the end of each treatment in a subset of participants (n=19). Results Compared with EPA, DHA increased LDL-C concentrations (+3.3%, P=0.038) and mean LDL particle size (+0.7 Å, P<0.001) and reduced the proportion of small LDL (-3.2%, P<0.01). Both EPA and DHA decreased proprotein convertase subtilisin/kexin type 9 concentrations similarly (-18.2% vs. -25.0%, P<0.0001 vs. control). Compared with EPA, DHA supplementation increased both LDL apo B-100 fractional catabolic rate (+11.4%, P=0.008) and production rate (+9.4%, P=0.03). Conclusions This study shows for the first time that supplementation with high-dose DHA increases LDL turnover and contributes to larger LDL particles compared with high-dose EPA. Copyright © 2018 Endocrine Society

Journal

Journal of Clinical Endocrinology and MetabolismOxford University Press

Published: May 25, 2018

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