Abstract Context Gut microbiota plays a major role in health and disease in by influencing physiology and metabolism, nutrition and immune function. Objective We aimed to evaluate the composition of gut microbiota in women with polycystic ovary syndrome (PCOS), focusing on the influence of sex, sex hormones and obesity on the associations found. Design Cross-sectional study Setting Academic hospital. Participants We recruited 16 non-hyperandrogenic control women, 15 women with PCOS, and 15 control men. Subjects were classified as non-obese (< 30 kg/m2) or obese (≥ 30 kg/m2) according to their body mass index (BMI). Interventions Standardization of diet for 3 consecutive days (at least 300g of carbohydrates per day) followed by fecal sampling and a standard 75-g oral glucose tolerance test. Main Outcome Measures Analysis of bacterial abundance and composition of gut microbiota by massive sequencing of 16S rDNA amplicons in a MiSeq Illumina platform. Results Alpha bacterial diversity was reduced in women compared with men, and beta diversity was reduced particularly in obese patients with PCOS. Women with PCOS presented with specific abnormalities in gut microbiota consisting of an increased abundance of the Catinebacterium and Kandleria genera. When considering all subjects as a whole, indexes of bacterial diversity and the abundance of several bacterial genera correlated positively with serum androgen concentrations and negatively with estradiol levels. Conclusions The diversity and composition of the gut microbiota of young adults are influenced by the combined effects of sex, sex hormone concentrations and obesity, presenting with specific abnormalities in women with PCOS. Copyright © 2018 Endocrine Society
Journal of Clinical Endocrinology and Metabolism – Oxford University Press
Published: Apr 20, 2018
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