Abstract Context and objektive Glucose-dependent insulinotropic polypeptide (GIP) in combination with hyperinsulinemia increase blood flow and triglyceride clearance in subcutaneous abdominal adipose tissue in lean humans. The present experiments were performed to determine whether the increase may involve capillary recruitment. Design Eight lean healthy volunteers were studied before and after 1-h infusion of GIP or saline during a hyperglycemic-hyperinsulinemic clamp, raising plasma glucose and insulin to postprandial levels. Abdominal subcutaneous adipose tissue blood flow (ATBF) was measured by the 133Xenon clearance technique, and microvascular volume was determined by contrast-enhanced ultrasound imaging. Results During infusion of saline and during the clamp, both ATBF (2.7 ± 0.5 ml min-1 100 g tissue-1) and microvascular volume remained unchanged throughout the experiments (P=NS). During GIP infusion plus clamp, ATBF increased ∼four fold to 11.4 ± 1.9 ml min-1 100 g tissue-1, P<0.001. Likewise, the contrast-enhanced ultrasound signal intensity, a measure of the microvascular volume, increased significantly one hour after infusion of GIP and the clamp (P=0.003), but not in control experiments. Conclusion The increase in ATBF during GIP infusion involves recruitment of capillaries in healthy lean subjects, which presumably increases the interaction of circulating lipoproteins with lipoprotein lipase thus probably promoting adipose tissue lipid uptake. Copyright © 2018 Endocrine Society
Journal of Clinical Endocrinology and Metabolism – Oxford University Press
Published: May 9, 2018
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera