Glucose-dependent insulinotropic polypeptide increases blood flow in adipose tissue of humans by recruiting capillaries

Glucose-dependent insulinotropic polypeptide increases blood flow in adipose tissue of humans by... Abstract Context and objektive Glucose-dependent insulinotropic polypeptide (GIP) in combination with hyperinsulinemia increase blood flow and triglyceride clearance in subcutaneous abdominal adipose tissue in lean humans. The present experiments were performed to determine whether the increase may involve capillary recruitment. Design Eight lean healthy volunteers were studied before and after 1-h infusion of GIP or saline during a hyperglycemic-hyperinsulinemic clamp, raising plasma glucose and insulin to postprandial levels. Abdominal subcutaneous adipose tissue blood flow (ATBF) was measured by the 133Xenon clearance technique, and microvascular volume was determined by contrast-enhanced ultrasound imaging. Results During infusion of saline and during the clamp, both ATBF (2.7 ± 0.5 ml min-1 100 g tissue-1) and microvascular volume remained unchanged throughout the experiments (P=NS). During GIP infusion plus clamp, ATBF increased ∼four fold to 11.4 ± 1.9 ml min-1 100 g tissue-1, P<0.001. Likewise, the contrast-enhanced ultrasound signal intensity, a measure of the microvascular volume, increased significantly one hour after infusion of GIP and the clamp (P=0.003), but not in control experiments. Conclusion The increase in ATBF during GIP infusion involves recruitment of capillaries in healthy lean subjects, which presumably increases the interaction of circulating lipoproteins with lipoprotein lipase thus probably promoting adipose tissue lipid uptake. Copyright © 2018 Endocrine Society http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Clinical Endocrinology and Metabolism Oxford University Press

Glucose-dependent insulinotropic polypeptide increases blood flow in adipose tissue of humans by recruiting capillaries

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Publisher
Oxford University Press
Copyright
Copyright © 2018 Endocrine Society
ISSN
0021-972X
eISSN
1945-7197
D.O.I.
10.1210/jc.2018-00389
Publisher site
See Article on Publisher Site

Abstract

Abstract Context and objektive Glucose-dependent insulinotropic polypeptide (GIP) in combination with hyperinsulinemia increase blood flow and triglyceride clearance in subcutaneous abdominal adipose tissue in lean humans. The present experiments were performed to determine whether the increase may involve capillary recruitment. Design Eight lean healthy volunteers were studied before and after 1-h infusion of GIP or saline during a hyperglycemic-hyperinsulinemic clamp, raising plasma glucose and insulin to postprandial levels. Abdominal subcutaneous adipose tissue blood flow (ATBF) was measured by the 133Xenon clearance technique, and microvascular volume was determined by contrast-enhanced ultrasound imaging. Results During infusion of saline and during the clamp, both ATBF (2.7 ± 0.5 ml min-1 100 g tissue-1) and microvascular volume remained unchanged throughout the experiments (P=NS). During GIP infusion plus clamp, ATBF increased ∼four fold to 11.4 ± 1.9 ml min-1 100 g tissue-1, P<0.001. Likewise, the contrast-enhanced ultrasound signal intensity, a measure of the microvascular volume, increased significantly one hour after infusion of GIP and the clamp (P=0.003), but not in control experiments. Conclusion The increase in ATBF during GIP infusion involves recruitment of capillaries in healthy lean subjects, which presumably increases the interaction of circulating lipoproteins with lipoprotein lipase thus probably promoting adipose tissue lipid uptake. Copyright © 2018 Endocrine Society

Journal

Journal of Clinical Endocrinology and MetabolismOxford University Press

Published: May 9, 2018

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