Ghrelin and Peptide YY Change During Puberty: Relationships with Adolescent Growth, Development and Obesity

Ghrelin and Peptide YY Change During Puberty: Relationships with Adolescent Growth, Development... Abstract Context Pubertal adolescents show strong appetites. How this is mediated is unclear, but ghrelin and peptide YY (PYY) play potentially important roles. Objective To measure ghrelin and PYY change in relation to pubertal growth. Design Three-year prospective cohort study. Setting Australian regional community. Participants Eighty healthy adolescents (26 girls; 54 boys) recruited at 10-13y. Main outcome measures Fasting circulating total ghrelin, total PYY, insulin-like growth factor 1 (IGF-1), insulin, leptin (via radioimmunoassay); estradiol and testosterone (via mass spectrometry); anthropometry and body composition (via bioelectrical impedance). Results Adolescents exhibited normal developmental change. Mixed models revealed positive associations for ghrelin to age2 (both sexes: p<0.05), indicating a U-shaped trend over time. Ghrelin was also inversely associated with IGF-1 (both sexes: p<0.05), leptin in girls (p<0.01), insulin in boys (p<0.05), and negatively correlated with annual height and weight velocity (both sexes: p≤0.01). PYY showed no age-related change in either sex. Neither ghrelin nor PYY were associated with Tanner stage. Weight subgroup analyses showed significant ghrelin associations with age2 in healthy weight but not overweight and obese (Ow/Ob) adolescents (7 girls; 18 boys). Conclusions Adolescents showed a U-shaped change in ghrelin corresponding to physical and biochemical markers of growth, and no change in PYY. The Ow/Ob subgroup exhibited an apparent loss of the U-shaped ghrelin trend, but this finding may be attributed to greater maturity and its clinical significance is unclear. Further research on weight-related ghrelin and PYY trends at puberty is needed to understand how these peptides influence growth and long-term metabolic risk. Copyright © 2018 Endocrine Society http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Clinical Endocrinology and Metabolism Oxford University Press

Ghrelin and Peptide YY Change During Puberty: Relationships with Adolescent Growth, Development and Obesity

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Publisher
Endocrine Society
Copyright
Copyright © 2018 Endocrine Society
ISSN
0021-972X
eISSN
1945-7197
D.O.I.
10.1210/jc.2017-01825
Publisher site
See Article on Publisher Site

Abstract

Abstract Context Pubertal adolescents show strong appetites. How this is mediated is unclear, but ghrelin and peptide YY (PYY) play potentially important roles. Objective To measure ghrelin and PYY change in relation to pubertal growth. Design Three-year prospective cohort study. Setting Australian regional community. Participants Eighty healthy adolescents (26 girls; 54 boys) recruited at 10-13y. Main outcome measures Fasting circulating total ghrelin, total PYY, insulin-like growth factor 1 (IGF-1), insulin, leptin (via radioimmunoassay); estradiol and testosterone (via mass spectrometry); anthropometry and body composition (via bioelectrical impedance). Results Adolescents exhibited normal developmental change. Mixed models revealed positive associations for ghrelin to age2 (both sexes: p<0.05), indicating a U-shaped trend over time. Ghrelin was also inversely associated with IGF-1 (both sexes: p<0.05), leptin in girls (p<0.01), insulin in boys (p<0.05), and negatively correlated with annual height and weight velocity (both sexes: p≤0.01). PYY showed no age-related change in either sex. Neither ghrelin nor PYY were associated with Tanner stage. Weight subgroup analyses showed significant ghrelin associations with age2 in healthy weight but not overweight and obese (Ow/Ob) adolescents (7 girls; 18 boys). Conclusions Adolescents showed a U-shaped change in ghrelin corresponding to physical and biochemical markers of growth, and no change in PYY. The Ow/Ob subgroup exhibited an apparent loss of the U-shaped ghrelin trend, but this finding may be attributed to greater maturity and its clinical significance is unclear. Further research on weight-related ghrelin and PYY trends at puberty is needed to understand how these peptides influence growth and long-term metabolic risk. Copyright © 2018 Endocrine Society

Journal

Journal of Clinical Endocrinology and MetabolismOxford University Press

Published: May 31, 2018

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