Fibroblast Growth Factor 2 and its Receptors in Bone Biology and Disease

Fibroblast Growth Factor 2 and its Receptors in Bone Biology and Disease Abstract The Fibroblast Growth Factor (FGF) regulatory axis is phylogenically ancient, evolving into a large mammalian/human gene family of 22 ligands that bind to four receptor tyrosine kinases for a complex physiological system controlling cell growth, differentiation and metabolism. The tissue targets for the primary FGF function are mainly cartilage and in bone for morphogenesis, mineralization and metabolism. A multitude of complexities in the FGF ligand-receptor-signaling pathways have made translation into therapies for FGF related bone disorders such as osteomalacia, osteoarthritis and osteoporosis difficult, but not prohibitive. Copyright © 2018 Endocrine Society http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of the Endocrine Society Oxford University Press

Fibroblast Growth Factor 2 and its Receptors in Bone Biology and Disease

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Publisher
Endocrine Society
Copyright
Copyright © 2018 Endocrine Society
eISSN
2472-1972
D.O.I.
10.1210/js.2018-00105
Publisher site
See Article on Publisher Site

Abstract

Abstract The Fibroblast Growth Factor (FGF) regulatory axis is phylogenically ancient, evolving into a large mammalian/human gene family of 22 ligands that bind to four receptor tyrosine kinases for a complex physiological system controlling cell growth, differentiation and metabolism. The tissue targets for the primary FGF function are mainly cartilage and in bone for morphogenesis, mineralization and metabolism. A multitude of complexities in the FGF ligand-receptor-signaling pathways have made translation into therapies for FGF related bone disorders such as osteomalacia, osteoarthritis and osteoporosis difficult, but not prohibitive. Copyright © 2018 Endocrine Society

Journal

Journal of the Endocrine SocietyOxford University Press

Published: May 28, 2018

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