Fasudil Slows Development of Cavernous Malformations

Fasudil Slows Development of Cavernous Malformations SCIENCE TIMES Unfortunately, this approach does not T-Vim trajectory, while sensory side exhibit an annual hemorrhage rate of account for interindividual anatomic effects were elicited in the target of the 2.5% (95% CI 1.3%-5.1%). Previous variability, and MRI limits visualization of conventional trajectory due to off-target hemorrhage has shown to be the most individual thalamic nuclei. Individualized sensory thalamus stimulation (Figures C significant hemorrhagic risk factor, while tractography may provide more robust and D). age, sex, location, size, and multiplicity anatomic data for targeting thalamic These findings support the use of deter- are less relevant. Hyperpermeability of nuclei. A recent study by Sammartino ministic tractography that relies on the CCM vessels occurs via the inactivation et al presents a novel method for deter- ML and PT internal landmarks to locate of ccm1, 2, or 3 genes and the subse- mining the tractography-based Vim target Vim in clinical settings. In particular, quent increase in RhoA activity and (T-Vim) for ultimate use in the clinical this new algorithm is an attractive alter- Rho-associated coiled-coil-forming kinase treatment of essential tremor. native to the existing probabilistic tractog- (ROCK). Multiple therapies based on T-Vim uses the pyramidal tract (PT) and raphy algorithms that are http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neurosurgery Oxford University Press

Fasudil Slows Development of Cavernous Malformations

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Publisher
Oxford University Press
Copyright
Copyright © 2017 by the Congress of Neurological Surgeons
ISSN
0148-396X
eISSN
1524-4040
D.O.I.
10.1093/neuros/nyx100
Publisher site
See Article on Publisher Site

Abstract

SCIENCE TIMES Unfortunately, this approach does not T-Vim trajectory, while sensory side exhibit an annual hemorrhage rate of account for interindividual anatomic effects were elicited in the target of the 2.5% (95% CI 1.3%-5.1%). Previous variability, and MRI limits visualization of conventional trajectory due to off-target hemorrhage has shown to be the most individual thalamic nuclei. Individualized sensory thalamus stimulation (Figures C significant hemorrhagic risk factor, while tractography may provide more robust and D). age, sex, location, size, and multiplicity anatomic data for targeting thalamic These findings support the use of deter- are less relevant. Hyperpermeability of nuclei. A recent study by Sammartino ministic tractography that relies on the CCM vessels occurs via the inactivation et al presents a novel method for deter- ML and PT internal landmarks to locate of ccm1, 2, or 3 genes and the subse- mining the tractography-based Vim target Vim in clinical settings. In particular, quent increase in RhoA activity and (T-Vim) for ultimate use in the clinical this new algorithm is an attractive alter- Rho-associated coiled-coil-forming kinase treatment of essential tremor. native to the existing probabilistic tractog- (ROCK). Multiple therapies based on T-Vim uses the pyramidal tract (PT) and raphy algorithms that are

Journal

NeurosurgeryOxford University Press

Published: May 1, 2017

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