Expression and Growth Stimulatory Effect of Fibroblast Growth Factor 9 in Human Brain Tumors

Expression and Growth Stimulatory Effect of Fibroblast Growth Factor 9 in Human Brain Tumors AbstractOBJECTIVEFibroblast giowth factor 9 (FGF-9) is a relatively new member of the FGF family isolated from the conditioned medium of a human glioblastoma cell line as a secreting type factor that exhibits a growth-stimulationed effect on primary glial celles. To elucidate the roles of FGF-9 in human brain tumors, the expression and biological activities of FGF-9 were studied using culture cell and surgically obtained tumors specimens. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neurosurgery Oxford University Press

Expression and Growth Stimulatory Effect of Fibroblast Growth Factor 9 in Human Brain Tumors

Expression and Growth Stimulatory Effect of Fibroblast Growth Factor 9 in Human Brain Tumors

e x p e r i m e n t a l s t u d i e s Expression and Growth Stimulatory Effect of Fibroblast Growth Factor 9 in Human Brain Tumors Tomoki Todo, M.D., Ph.D., Tatsuya Kondo, M.D., Ph.D., Takaaki Kirino, M.D., Ph.D., Akio Asai, M.D., Ph.D., Eric F. Adams, Ph.D., Satoshi Nakamura, M.D., Kazuhiko Ikeda, M.D., Ph.D., Tsutomu Kurokawa, Ph.D. Department of Neurosurgery (TT, TKo), International Medical Center of Japan, Tokyo, Japan; Department of Neurosurgery (TT, TKi, AA), University of Tokyo, Tokyo, Japan; Department of Neurosurgery (EFA), University of Erlangen-Niirnberg, Erlangen, Germany; Department of Ultrastructure and Histochemistry (SN, Kl), Tokyo Institute of Psychiatry, Tokyo, Japan; and Discovery Research Laboratories I (TKu), Takeda Chemical Industries, Ltd., Tsukuba, Japan k r of the FG F family isolated from the OBIECTIVE: Fibroblast g io w th ^ ^ b t e t o m a ' c a M i n e a sbnwlatin^effeUola prim ary 8*'^* f j- ^ o f ^ e l^ c u lt u r e ^ w a s p e rfu m e d b y'u sb ig a and biological activities of F jn condlt,oned media o „ wth studies. F G F -9 METHODS: Measurement of F G F -9 and n ic effect 0f FG F-9 was evaluate y sandwich enzyme im m “ noaS^ ; atede by immunohistochemistry. actually secreted detectable amounts expression in vivo was demons human meningiomas exami „i:nma cell lines and 1 1 of 16 RESULTS: One of 4 gliom a cell production was in vitro cell of FGF-9 proteins. In c o m p a r i s o n , has eCombinant human FG F-9 sigmt J time course growth human meningiomas. Sim ilarly to asic ' investigated in a dos? ' dpPe Fnq e,I Day 4 The growth stimulatory proliferation in tbree o f four g - c e l U m e ^ ^ b for FG F-9 study using U87 MG cells reveale meningiomas studied. Mod »,,mnr tv n e erade of malignancy, activity was also shown in three o our turnors examined irrespective o or,81 "' s - |n tbe normal human was observed in 40 (8 2 % ) of 49 human brain tamo immunostaining was...
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Publisher
Congress of Neurological Surgeons
Copyright
© Published by Oxford University Press.
ISSN
0148-396X
eISSN
1524-4040
D.O.I.
10.1097/00006123-199808000-00098
Publisher site
See Article on Publisher Site

Abstract

AbstractOBJECTIVEFibroblast giowth factor 9 (FGF-9) is a relatively new member of the FGF family isolated from the conditioned medium of a human glioblastoma cell line as a secreting type factor that exhibits a growth-stimulationed effect on primary glial celles. To elucidate the roles of FGF-9 in human brain tumors, the expression and biological activities of FGF-9 were studied using culture cell and surgically obtained tumors specimens.

Journal

NeurosurgeryOxford University Press

Published: Aug 1, 1998

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