Abstract Context Menopause is associated with an increased incidence of insulin resistance and diabetes. Objective The aim of this study was to explore the lipid deposition in liver and skeletal muscle and investigate the association with insulin sensitivity in post- and premenopausal women. Design, setting, participants and measurements Single-centre cross-sectional study of 55 healthy women between 45- and 60 years of age. We measured lipid deposition in the liver with MR spectroscopy, intramuscular- and intraabdominal lipid deposition with MRI, body composition with a DEXA-scan and insulin sensitivity with the composite Matsuda Index. Outcomes We studied the association between fat distribution, ectopic lipid deposition and insulin sensitivity in pre- and postmenopausal women. Results Postmenopausal women had an increased lipid deposition in the liver (0.68% (0.44-0.99) vs. 0.49% (0.38-0.64), p=0.01) and skeletal muscle (3% (2-4) vs. 2% (1-3), p=0.001) and had a 28% lower Matsuda insulin sensitivity index during an OGTT (6.31±3.48 vs. 8.78±4.67, p=0.05) compared to premenopausal women. Total fat mass and leg fat mass were stronger predictors of ectopic lipid deposition and visceral fat mass was a stronger predictor of both ectopic lipid deposition and insulin resistance in postmenopausal women compared to premenopausal women. Conclusions For a given sub cutaneous- and visceral fat depot size, postmenopausal women show increased ectopic lipid deposition and -insulin resistance compared to premenopausal women. It is suggested that lipid deposition in liver and skeletal muscle may represent important mechanistic links between the changes in fat depots and the increased incidence of insulin resistance seen after menopause. Copyright © 2018 Endocrine Society
Journal of Clinical Endocrinology and Metabolism – Oxford University Press
Published: Jun 7, 2018
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera