QJM: An International Journal of Medicine, 2018, 143 doi: 10.1093/qjmed/hcy042 Elements: in this month’s issue ELEMENTS : IN THI S MONTH ’ S I SSUE S.C. Donnelly Editor-in-Chief, QJM ‘Between two evils, I always pick the one I never tried before’. subsequent in vitro and in vivo experiments, we are beginning to Mae West, Actress understand the precise mechanisms at the cellular level which (1893–1980) underline this therapeutic activity. Hu and colleagues from the ‘Constantly choosing the lesser of two evils is still choosing evil’. Jiangsu Academy of Agricultural Sciences extend this work by Jerry Garcia, Singer, Grateful Dead reporting in this issue on activated endothelial cells pre-treated (1942–95) with Sinomenine. This is a compound extracted from the plant, Currently, up to 20% of smokers in the UK have used e-cigar- Sinomenium acutum, that has been shown to have significant ettes and vaping devices. Proponents for e-cigarettes highlight anti-inflammatory activity. Lipolysaccharide is derived from the the main advantage being harm reduction globally compared cell membrane of Gram-negative bacteria. In this work, it was with standard cigarettes—the lesser of two evils. utilized to activate the endothelial cells. What the results show The Journal has provided a platform for publishing manu- is that this herbal extract has significant capacity to down- scripts highlighting the epidemiology, changing practices and regulate the inflammatory response particularly in reducing in- 2–5 management of recreational drug use in Western society. We flammatory cytokine expression, suppressing the transcription continue this practice with an authorative review by Blundell of apoptosis genes, accelerating the synthesis of protein and and colleagues on the current use of vaping devices in recre- enhancing the energy metabolism of cells. The QJM welcomes ational drug usage today. These devices initially were designed the submission of similar articles that add to our expanding to mimic in appearance standard cigarettes. But more recent knowledge of the mechanisms for historical Chinese therapies. designs have become more complex and many now incorporate the ability to regulate the vapourization temperature. This then References allows the device to be used to vapourize recreational drugs, such as cannabis resin. In 2015/2016, a survey of British adult 1. Clancy L, Babineau K. E-cigarettes: effective cessation tools or subjects aged 16–59 reported 35% lifetime use of illicit drug use. public health threat? QJM 2016; 109:79–81. In surveys of young adults in the USA, between 20% and 30% of 2. Blundell M, Dargan P, Wood D. A cloud on the horizon-a survey e-cigarette users report vaping cannabis leaves/resin. There is into the use of electronic vaping devices for recreational drug also more recent evidence of experimentation with vaping and new psychoactive substance (NPS) administration. QJM synthetic cannabinoids and psychoactive drugs. In their review, 2018; 111:9–14. the authors argue that we need more accurate real-time data to 3. Haden M, Wood DM, Dargan PI. The impact of the define public health risk and consequently devise appropriate Psychoactive Substances Act 2016 on the online availability of national and global public health strategies. MDMB-CHMICA. QJM 2017; 110:619–22. 4. Wood DM, Ceronie B, Dargan PI. Healthcare professionals are less conﬁdent in managing acute toxicity related to the use of Chinese herbal medicine and antibacterial new psychoactive substances (NPS) compared with classical properties recreational drugs. QJM 2016; 109:527–9. It has long been recognized that traditional Chinese herbal 5. Penney J, Dargan PI, Padmore J, Wood DM, Norman IJ. Epidemiology of adolescent substance use in London schools. medicines have significant anti-inflammatory and in particular antibacterial activity. Using modern array technologies and QJM 2016; 109:405–9. V C The Author(s) 2018. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For Permissions, please email: firstname.lastname@example.org Downloaded from https://academic.oup.com/qjmed/article-abstract/111/3/143/4917351 by Ed 'DeepDyve' Gillespie user on 16 March 2018
QJM: An International Journal of Medicine – Oxford University Press
Published: Mar 1, 2018
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