Detection of Incident Anal High-Risk HPV-DNA in MSM: Incidence or Reactivation?

Detection of Incident Anal High-Risk HPV-DNA in MSM: Incidence or Reactivation? Abstract Background We aimed to assess whether sexual exposure may explain all incident anal HPV detections among men who have sex with men (MSM). Methods A longitudinal study among MSM was conducted between 2010 and 2013 with six-monthly visits and up to 24 months of follow-up. Risk-factor questionnaires, blood samples, and anal and penile self-swabs were collected at each visit. Self-swabs were used for detection and genotyping of HPV by SPF10-PCR/DEIA/LiPA25 system. Serum samples were tested for high-risk (hr)HPV antibodies. Incident anal HPV detection rates among sexually non-, low and highly exposed MSM were compared. Factors associated with incident anal hrHPV detection were assessed using multivariable Cox regression. Results 714 men (median age 40 years; 39% HIV positive) were included in the analysis. Incident anal detections of all hrHPV-types were observed among both sexually non-exposed and exposed MSM. In multivariable analyses, highly sexually exposed, being HIV-infected and having a penile HPV infection were positively associated with incident anal HPV detection; those reporting more sex partners had a non-significantly increased risk of HPV detection. Conclusion Incident anal hrHPV detection is common among recently non-exposed MSM, suggesting that a reactivated latent HPV infection instead of an incident infection may underlie incident HPV detection. HPV, HIV, incidence rate, men who have sex with men, anus, latency © The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/about_us/legal/notices) http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Infectious Diseases Oxford University Press

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Publisher
Oxford University Press
Copyright
© The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
ISSN
0022-1899
eISSN
1537-6613
D.O.I.
10.1093/infdis/jiy276
Publisher site
See Article on Publisher Site

Abstract

Abstract Background We aimed to assess whether sexual exposure may explain all incident anal HPV detections among men who have sex with men (MSM). Methods A longitudinal study among MSM was conducted between 2010 and 2013 with six-monthly visits and up to 24 months of follow-up. Risk-factor questionnaires, blood samples, and anal and penile self-swabs were collected at each visit. Self-swabs were used for detection and genotyping of HPV by SPF10-PCR/DEIA/LiPA25 system. Serum samples were tested for high-risk (hr)HPV antibodies. Incident anal HPV detection rates among sexually non-, low and highly exposed MSM were compared. Factors associated with incident anal hrHPV detection were assessed using multivariable Cox regression. Results 714 men (median age 40 years; 39% HIV positive) were included in the analysis. Incident anal detections of all hrHPV-types were observed among both sexually non-exposed and exposed MSM. In multivariable analyses, highly sexually exposed, being HIV-infected and having a penile HPV infection were positively associated with incident anal HPV detection; those reporting more sex partners had a non-significantly increased risk of HPV detection. Conclusion Incident anal hrHPV detection is common among recently non-exposed MSM, suggesting that a reactivated latent HPV infection instead of an incident infection may underlie incident HPV detection. HPV, HIV, incidence rate, men who have sex with men, anus, latency © The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/about_us/legal/notices)

Journal

The Journal of Infectious DiseasesOxford University Press

Published: May 16, 2018

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