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Cover the Journals of Gerontology series a • BIOLOGICAL SCIENCES and MEDICAL SCIENCES • VOLUME 72, NO. 11, NOVEMBER 2017 ISSN 1079-5006 PRINT ISSN 1758-535X ONLINE VOL. 72 NO. 11 NOVEMBER 2017 VOLUME 72 • NUMBER 11 • NOVEMBER 2017 contents The Journals of THE JOURNAL OF GERONTOLOGY: BIOLOGICAL SCIENCES 1453 Editor’s Choice Four Genome-Wide Association Studies Identify New Extreme Longevity Variants Paola Sebastiani, Anastasia Gurinovich, Harold Bae, Stacy Andersen, Alberto Malovini, Gil Atzmon, Francesco Villa, Aldi T. Kraja, Danny Ben- Avraham, Nir Barzilai, Annibale Puca, and Thomas T. Perls 1456 Pregnancy at Advanced Maternal Age Affects Behavior and Hippocampal Gene Expression in Mouse Offspring Silvestre Sampino, Adrian Mateusz Stankiewicz, Federica Zacchini, Joanna Goscik, Agnieszka Szostak, Artur Hugo Swiergiel, Gaspare Drago, Jacek Andrzej Modlinski, and Grazyna Ewa Ptak 1474 Biological Aging and the Human Gut Microbiota Vincent J. Maffei, Sangkyu Kim, Eugene Blanchard IV, Meng Luo, S. Michal Jazwinski, Christopher M. Taylor, and David A. Welsh GERONTOLOGY 1483 Comprehensive miRNA Profiling of Skeletal Muscle and Serum in Induced and Normal Mouse Muscle Atrophy During Aging Hwa Jin Jung, Kwang-Pyo Lee, Brandon Milholland, Yeo Jin Shin, Jae Sook Kang, Ki-Sun Kwon, and Yousin Suh 1492 The Intersection of Aging Biology and the Pathobiology of Lung Diseases: A Joint NHLBI/NIA Workshop G.R. Scott Budinger, Ronald A. Kohanski, Weiniu Gan, Michael S. Kobor, Luis A. Amaral, Mary Armanios, Karl T. Kelsey, Annie Pardo, Rubin Tuder, Fernando Macian, Navdeep Chandel, Douglas Vaughan, Mauricio Rojas, Ana L. Mora, Elizabeth Kovacs, Steven R. Duncan, Biological Sciences & Medical Sciences Toren Finkel, Augustine Choi, Oliver Eickelberg, Danica Chen, Alvar Agusti, Moises Selman, William E. Balch, Paula Busse, Anning Lin, Richard Morimoto, Jacob I. Sznajder, and Victor J. Thannickal VOLUME 72 • NUMBER 11 • NOVEMBER 2017 contents THE JOURNAL OF GERONTOLOGY: TRANSLATIONAL SECTION: SERIES STEM CELL TRANSPLANTATION FOR FRAILTY 1503 Stem Cell Transplantation for Frailty David G. Le Couteur, Rozalyn M. Anderson, Anne B. Newman, and Rafael de Cabo 1505 Allogeneic Human Mesenchymal Stem Cell Infusions for Aging Frailty Samuel Golpanian, Darcy L. DiFede, Aisha Khan, Ivonne Hernandez Schulman, Ana Marie Landin, Bryon A. Tompkins, Alan W. Heldman, Roberto Miki, Bradley J. Goldstein, Muzammil Mushtaq, Silvina Levis-Dusseau, John J. Byrnes, Maureen Lowery, Makoto Natsumeda, Cindy Delgado, Russell Saltzman, Mayra Vidro-Casiano, Marietsy V. Pujol, Moisaniel Da Fonseca, Anthony A. Oliva, Geoff Green, Courtney Premer, Audrey Medina, Krystalenia Valasaki, Victoria Florea, Erica Anderson, Jill El-Khorazaty, Adam Mendizabal, Pascal J. Goldschmidt-Clermont, and Joshua M. Hare 1513 Allogeneic Mesenchymal Stem Cells Ameliorate Aging Frailty: A Phase II Randomized, Double-Blind, Placebo-Controlled Clinical Trial Bryon A. Tompkins, Darcy L. DiFede, Aisha Khan, Ana Marie Landin, Ivonne Hernandez Schulman, Marietsy V. Pujol, Alan W. Heldman, Roberto Miki, Pascal J. Goldschmidt-Clermont, Bradley J. Goldstein, Muzammil Mushtaq, Silvina Levis-Dusseau, John J. Byrnes, Maureen Lowery, Makoto Natsumeda, Cindy Delgado, Russell Saltzman, Mayra Vidro-Casiano, Moisaniel Da Fonseca, Samuel Golpanian, Courtney Premer, Audrey Medina, Krystalenia Valasaki, Victoria Florea, Erica Anderson, Jill El-Khorazaty, Adam Mendizabal, Geoff Green, Anthony A. Oliva, and Joshua M. Hare VOLUME 72 • NUMBER 11 • NOVEMBER 2017 contents THE JOURNAL OF GERONTOLOGY: MEDICAL SCIENCES 1525 Editor’s Choice Low Normalized Grip Strength is a Biomarker for Cardiometabolic Disease and Physical Disabilities Among U.S. and Chinese Adults Mark D. Peterson, Kate Duchowny, Qinqin Meng, Yafeng Wang, Xinxin Chen, and Yaohui Zhao 1532 Association of Accelerometer-Measured Physical Activity With Leukocyte Telomere Length Among Older Women Aladdin H. Shadyab, Michael J. LaMonte, Charles Kooperberg, Alexander P. Reiner, Cara L. Carty, Todd M. Manini, Lifang Hou, Chongzhi Di, and Andrea Z. LaCroix 1538 Evaluating Distinctions in the Assessment of Late-Life Disability Thomas M. Gill and Christianna S. Williams 1547 Community Weight Loss to Combat Obesity and Disability in At-Risk Older Adults W. Jack Rejeski, Walter T. Ambrosius, Jonathan H. Burdette, Michael P. Walkup, and Anthony P. Marsh 1554 Kidney Function Estimated From Cystatin C, But Not Creatinine, Is Related to Objective Tests of Physical Performance in Community- Dwelling Older Adults Mark Canney, Donal J. Sexton, Matthew DL. O’Connell, Rose Anne Kenny, Mark A. Little, and Conall M. O’Seaghdha 1561 Genetic and Environmental Effects on Telomere Length and Lung Function: A Twin Study Elina Sillanpää, Sarianna Sipilä, Timo Törmäkangas, Jaakko Kaprio, and Taina Rantanen 1569 Body Mass Index and Waist Circumference as Predictors of Disability in Nonagenarians: The Vitality 90+ Study Inna Lisko, Kristina Tiainen, Jani Raitanen, Juulia Jylhävä, Mikko Hurme, Antti Hervonen, Marja Jylhä, and Sari Stenholm 1575 Prevalence and Clinical Correlates of Sarcopenia, Identified According to the EWGSOP Definition and Diagnostic Algorithm, in Hospitalized Older People: The GLISTEN Study Lara Bianchi, Pasquale Abete, Giuseppe Bellelli, Mario Bo, Antonio Cherubini, Francesco Corica, Mauro Di Bari, Marcello Maggio, Giovanna Maria Manca, Maria Rosaria Rizzo, Andrea P. Rossi, Francesco Landi, and Stefano Volpato; for the GLISTEN Group Investigators 1582 Change in Bone Mineral Density During Weight Loss with Resistance Versus Aerobic Exercise Training in Older Adults Kristen M. Beavers, Daniel P. Beavers, Sarah B. Martin, Anthony P. Marsh, Mary F. Lyles, Leon Lenchik, Sue A. Shapses, and Barbara J. Nicklas 1586 Baseline Characteristics of Participants in the ASPREE (ASPirin in Reducing Events in the Elderly) Study John J. McNeil, Robyn L. Woods, Mark R. Nelson, Anne M. Murray, Christopher M. Reid, Brenda Kirpach, Elsdon Storey, Raj C. Shah, Rory S. Wolfe, Andrew M. Tonkin, Anne B. Newman, Jeff D. Williamson, Jessica E. Lockery, Karen L. Margolis, Michael E. Ernst, Walter P. Abhayaratna, Nigel Stocks, Sharyn M. Fitzgerald, Ruth E. Trevaks, Suzanne G. Orchard, Lawrence J. Beilin, Geoffrey A. Donnan, Peter Gibbs, Colin I. Johnston, and Richard H. Grimm; on behalf of the ASPREE Investigator Group http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences Oxford University Press

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Abstract

the Journals of Gerontology series a • BIOLOGICAL SCIENCES and MEDICAL SCIENCES • VOLUME 72, NO. 11, NOVEMBER 2017 ISSN 1079-5006 PRINT ISSN 1758-535X ONLINE VOL. 72 NO. 11 NOVEMBER 2017 VOLUME 72 • NUMBER 11 • NOVEMBER 2017 contents The Journals of THE JOURNAL OF GERONTOLOGY: BIOLOGICAL SCIENCES 1453 Editor’s Choice Four Genome-Wide Association Studies Identify New Extreme Longevity Variants Paola Sebastiani, Anastasia Gurinovich, Harold Bae, Stacy Andersen, Alberto Malovini, Gil Atzmon, Francesco Villa, Aldi T. Kraja, Danny Ben- Avraham, Nir Barzilai, Annibale Puca, and Thomas T. Perls 1456 Pregnancy at Advanced Maternal Age Affects Behavior and Hippocampal Gene Expression in Mouse Offspring Silvestre Sampino, Adrian Mateusz Stankiewicz, Federica Zacchini, Joanna Goscik, Agnieszka Szostak, Artur Hugo Swiergiel, Gaspare Drago, Jacek Andrzej Modlinski, and Grazyna Ewa Ptak 1474 Biological Aging and the Human Gut Microbiota Vincent J. Maffei, Sangkyu Kim, Eugene Blanchard IV, Meng Luo, S. Michal Jazwinski, Christopher M. Taylor, and David A. Welsh GERONTOLOGY 1483 Comprehensive miRNA Profiling of Skeletal Muscle and Serum in Induced and Normal Mouse Muscle Atrophy During Aging Hwa Jin Jung, Kwang-Pyo Lee, Brandon Milholland, Yeo Jin Shin, Jae Sook Kang, Ki-Sun Kwon, and Yousin Suh 1492 The Intersection of Aging Biology and the Pathobiology of Lung Diseases: A Joint NHLBI/NIA Workshop G.R. Scott Budinger, Ronald A. Kohanski, Weiniu Gan, Michael S. Kobor, Luis A. Amaral, Mary Armanios, Karl T. Kelsey, Annie Pardo, Rubin Tuder, Fernando Macian, Navdeep Chandel, Douglas Vaughan, Mauricio Rojas, Ana L. Mora, Elizabeth Kovacs, Steven R. Duncan, Biological Sciences & Medical Sciences Toren Finkel, Augustine Choi, Oliver Eickelberg, Danica Chen, Alvar Agusti, Moises Selman, William E. Balch, Paula Busse, Anning Lin, Richard Morimoto, Jacob I. Sznajder, and Victor J. Thannickal VOLUME 72 • NUMBER 11 • NOVEMBER 2017 contents THE JOURNAL OF GERONTOLOGY: TRANSLATIONAL SECTION: SERIES STEM CELL TRANSPLANTATION FOR FRAILTY 1503 Stem Cell Transplantation for Frailty David G. Le Couteur, Rozalyn M. Anderson, Anne B. Newman, and Rafael de Cabo 1505 Allogeneic Human Mesenchymal Stem Cell Infusions for Aging Frailty Samuel Golpanian, Darcy L. DiFede, Aisha Khan, Ivonne Hernandez Schulman, Ana Marie Landin, Bryon A. Tompkins, Alan W. Heldman, Roberto Miki, Bradley J. Goldstein, Muzammil Mushtaq, Silvina Levis-Dusseau, John J. Byrnes, Maureen Lowery, Makoto Natsumeda, Cindy Delgado, Russell Saltzman, Mayra Vidro-Casiano, Marietsy V. Pujol, Moisaniel Da Fonseca, Anthony A. Oliva, Geoff Green, Courtney Premer, Audrey Medina, Krystalenia Valasaki, Victoria Florea, Erica Anderson, Jill El-Khorazaty, Adam Mendizabal, Pascal J. Goldschmidt-Clermont, and Joshua M. Hare 1513 Allogeneic Mesenchymal Stem Cells Ameliorate Aging Frailty: A Phase II Randomized, Double-Blind, Placebo-Controlled Clinical Trial Bryon A. Tompkins, Darcy L. DiFede, Aisha Khan, Ana Marie Landin, Ivonne Hernandez Schulman, Marietsy V. Pujol, Alan W. Heldman, Roberto Miki, Pascal J. Goldschmidt-Clermont, Bradley J. Goldstein, Muzammil Mushtaq, Silvina Levis-Dusseau, John J. Byrnes, Maureen Lowery, Makoto Natsumeda, Cindy Delgado, Russell Saltzman, Mayra Vidro-Casiano, Moisaniel Da Fonseca, Samuel Golpanian, Courtney Premer, Audrey Medina, Krystalenia Valasaki, Victoria Florea, Erica Anderson, Jill El-Khorazaty, Adam Mendizabal, Geoff Green, Anthony A. Oliva, and Joshua M. Hare VOLUME 72 • NUMBER 11 • NOVEMBER 2017 contents THE JOURNAL OF GERONTOLOGY: MEDICAL SCIENCES 1525 Editor’s Choice Low Normalized Grip Strength is a Biomarker for Cardiometabolic Disease and Physical Disabilities Among U.S. and Chinese Adults Mark D. Peterson, Kate Duchowny, Qinqin Meng, Yafeng Wang, Xinxin Chen, and Yaohui Zhao 1532 Association of Accelerometer-Measured Physical Activity With Leukocyte Telomere Length Among Older Women Aladdin H. Shadyab, Michael J. LaMonte, Charles Kooperberg, Alexander P. Reiner, Cara L. Carty, Todd M. Manini, Lifang Hou, Chongzhi Di, and Andrea Z. LaCroix 1538 Evaluating Distinctions in the Assessment of Late-Life Disability Thomas M. Gill and Christianna S. Williams 1547 Community Weight Loss to Combat Obesity and Disability in At-Risk Older Adults W. Jack Rejeski, Walter T. Ambrosius, Jonathan H. Burdette, Michael P. Walkup, and Anthony P. Marsh 1554 Kidney Function Estimated From Cystatin C, But Not Creatinine, Is Related to Objective Tests of Physical Performance in Community- Dwelling Older Adults Mark Canney, Donal J. Sexton, Matthew DL. O’Connell, Rose Anne Kenny, Mark A. Little, and Conall M. O’Seaghdha 1561 Genetic and Environmental Effects on Telomere Length and Lung Function: A Twin Study Elina Sillanpää, Sarianna Sipilä, Timo Törmäkangas, Jaakko Kaprio, and Taina Rantanen 1569 Body Mass Index and Waist Circumference as Predictors of Disability in Nonagenarians: The Vitality 90+ Study Inna Lisko, Kristina Tiainen, Jani Raitanen, Juulia Jylhävä, Mikko Hurme, Antti Hervonen, Marja Jylhä, and Sari Stenholm 1575 Prevalence and Clinical Correlates of Sarcopenia, Identified According to the EWGSOP Definition and Diagnostic Algorithm, in Hospitalized Older People: The GLISTEN Study Lara Bianchi, Pasquale Abete, Giuseppe Bellelli, Mario Bo, Antonio Cherubini, Francesco Corica, Mauro Di Bari, Marcello Maggio, Giovanna Maria Manca, Maria Rosaria Rizzo, Andrea P. Rossi, Francesco Landi, and Stefano Volpato; for the GLISTEN Group Investigators 1582 Change in Bone Mineral Density During Weight Loss with Resistance Versus Aerobic Exercise Training in Older Adults Kristen M. Beavers, Daniel P. Beavers, Sarah B. Martin, Anthony P. Marsh, Mary F. Lyles, Leon Lenchik, Sue A. Shapses, and Barbara J. Nicklas 1586 Baseline Characteristics of Participants in the ASPREE (ASPirin in Reducing Events in the Elderly) Study John J. McNeil, Robyn L. Woods, Mark R. Nelson, Anne M. Murray, Christopher M. Reid, Brenda Kirpach, Elsdon Storey, Raj C. Shah, Rory S. Wolfe, Andrew M. Tonkin, Anne B. Newman, Jeff D. Williamson, Jessica E. Lockery, Karen L. Margolis, Michael E. Ernst, Walter P. Abhayaratna, Nigel Stocks, Sharyn M. Fitzgerald, Ruth E. Trevaks, Suzanne G. Orchard, Lawrence J. Beilin, Geoffrey A. Donnan, Peter Gibbs, Colin I. Johnston, and Richard H. Grimm; on behalf of the ASPREE Investigator Group

Journal

The Journals of Gerontology Series A: Biomedical Sciences and Medical SciencesOxford University Press

Published: Oct 12, 2017

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