Alcohol and Alcoholism, 2018, 53(4) 500 doi: 10.1093/alcalc/agy030 Advance Access Publication Date: 27 April 2018 Corrigendum: Comparing and Combining Topiramate and Aripiprazole on Alcohol-Related Outcomes in a Human Laboratory Study 1,2,3, 2,3 1 2,3 Carolina L. Haass-Kofﬂer , Kimberly Goodyear , William H. Zywiak , Lorenzo Leggio , 1 1,4 George A. Kenna , and Robert M. Swift Center for Alcohol and Addiction Studies, Department of Psychiatry and Human Behavior, Brown University, Providence, RI, USA, Center for Alcohol and Addiction Studies, Department of Behavioral and Social Sciences, Brown University, Providence, RI, USA, Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology, National Institute on Alcohol Abuse and Alcoholism; and National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD, USA, and Veterans Affairs Medical Center, Providence, RI, USA *Corresponding author: Center for Alcohol and Addiction Studies, Department Psychiatry and Human Behavior, Brown University, 121 South Main Street, Providence, RI 02912, USA. Tel: 401-863-6624; Fax: 401-863-6647; E-mail: carolina_haass-kofﬂer@brown.edu Alcohol and Alcoholism, 2015, 50(4): 458–462, doi: 10.1093/alcalc/agx108 In our manuscript (Haass-Kofﬂer et al., 2017), we report that after collapsed. Of note, the reduction of BMI by 0.36 (0.16), which is 4 week titration and 1 week at target dose, there was a signiﬁcant ~1 kg for an average person, would not affect amount of alcohol main effect for topiramate in decreasing body mass index (BMI). consumed in the laboratory (priming drink) since it would have However, we did not specify how much BMIs declined. This infor- inﬂuenced minimally the calculation of the alcohol to be adminis- mation is important to report as the amount of the self-administered tered as standard unit drink. For example, in a 45-year-old male, alcohol was adjusted based on body water during the human weight 80 Kg, height 1.75 m (BMI = 26.1), according to the Watson laboratory phase and the calculation is in part based on body equation (Watson et al., 1981), the calculated amount of alcohol in weight. This information could be relevant to the study ﬁndings that the priming dose correspond to 16.6 g. For the same male, the topiramate 200 mg/day reduced alcohol consumption and lessened reduction of BMI by 0.36 (BMI = 25.8), the amount of alcohol in alcohol craving in the naturalistic phase, but not in the human the priming dose would correspond to 16.4 g (0.2 g difference). laboratory phase. At Week 5, there was a signiﬁcant main effect for topiramate on BMI [F = 6.07, P = 0.019] with aripiprazole as covariate and 1,37 REFERENCES interaction with time, see manuscript for statistical approach Haass-Kofﬂer CL, Goodyear K, Zywiak WH, et al. (2017) Comparing and (Haass-Kofﬂer et al., 2017). The topiramate group showed a mean combining topiramate and aripiprazole on alcohol-related outcomes in a BMI loss of 0.36 (0.16 SD) while groups not receiving topiramate human laboratory study. Alcohol Alcohol. (aripiprazole and placebo) showed a mean BMI gain of 0.32 (0.22 Watson PE, Watson ID, Batt RD. (1981) Prediction of blood alcohol concen- SD) from baseline. The signiﬁcant reduction of BMI, was observed trations in human subjects. Updating the Widmark Equation. J Stud only when the topiramate doses (100 mg and 200 mg) were Alcohol 42:547–56. Downloaded from https://academic.oup.com/alcalc/article-abstract/53/4/500/4989376 by Ed 'DeepDyve' Gillespie user on 26 June 2018
Alcohol and Alcoholism – Oxford University Press
Published: Apr 27, 2018
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