Cerebrovascular Biology and the Various Neural Barriers: Challenges and Future Directions

Cerebrovascular Biology and the Various Neural Barriers: Challenges and Future Directions AbstractDESPITE MAJOR ADVANCES in neuroscience, potential therapeutic options for the treatment of central nervous system diseases often cannot be optimized secondary to the presence of the blood-brain barrier (BBB). During the next decade of inquiry, it is crucial that basic science and clinical research that is focused on overcoming the BBB, to optimize delivery to the central nervous system, be identified and supported as a priority topic. For this reason, the third international Cerebrovascular Biology and Blood-Brain Barrier Conference was convened in March 1998 in Gleneden Beach, OR. This meeting brought together basic science and clinical researchers from around the world to analyze BBB function and to discuss delivery of effective agents to the central nervous system for treatment ot brain disease. This report summarizes the information presented at the meeting and the discussions that ensued. The current state of knowledge, obstacles to further understanding the BBB, and research priorities are identified. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neurosurgery Oxford University Press

Cerebrovascular Biology and the Various Neural Barriers: Challenges and Future Directions

Cerebrovascular Biology and the Various Neural Barriers: Challenges and Future Directions

SPECIAL REPORT Cerebrovascular Biology and the Challenges and Futui Edward A. Neuwelt, M .D ., N. Joan Abbott, Ph.D., Lester Drewes, Ph.D., Quentin R. Smith, Ph.D., Pierre O . Couraud, Ph.D., E. Antonio Chiocca, Ph.D., Kenneth L. Audus, Ph.D., Nigel H. Greig, Ph.D., Nancy D. Doolittle, Ph.D. Oregon Health Sciences U n iversity (EA N , N D D ), Portland, O regon; Kings C o lleg e (N )A), London, England; U n iversity of M innesota (LD ), D u lu th , M innesota; T exas Tech U n iversity Health S cie n ce Center (Q R S), A m a rillo , T e xa s; Institut C o c h in de C enetiq u e M o lecu laire (P O C ), Paris, France; M assachusetts G en eral Hospital (EA C ), C harlesto w n, M assachusetts; U n iversity of Kansas (K LA ), La w re n ce , Kansas; and National Institute on Aging (N H G ), Bethesda, M aryland D ESPITE M A JO R A D V A N C ES in neuroscience, potential therapeutic options for the treatment of central nervous system diseases often cannot be optimized secondary to the presence of the blood-brain barrier (B B B ). During the next decade of inquiry, it is crucial that basic science and clinical research that is focused on overcom ing the BBB, to optimize delivery to the central nervous system, be identified and supported as a priority topic. For this reason, the third international Cerebrovascular Biology and Blood-Brain Barrier Conference was convened in March 1998 in Gleneden Beach, O R. This meeting brought together basic science and clinical researchers from around the world to analyze B B B function and to discuss delivery of effective agents to the central nervous system for treatment ot brain disease. This report summarizes the information presented at the meeting and the discussions that ensued. The current state of knowledge, obstacles to further understanding the B B B , and research priorities are identified. (Neurosurgery 44:604-609, 1999) Key words: Blood-brain barrier, Cerebrovascular biology, Neural barriers O V E R V IE W O F THE V A R IO U...
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Publisher
Congress of Neurological Surgeons
Copyright
© Published by Oxford University Press.
ISSN
0148-396X
eISSN
1524-4040
D.O.I.
10.1097/00006123-199903000-00095
Publisher site
See Article on Publisher Site

Abstract

AbstractDESPITE MAJOR ADVANCES in neuroscience, potential therapeutic options for the treatment of central nervous system diseases often cannot be optimized secondary to the presence of the blood-brain barrier (BBB). During the next decade of inquiry, it is crucial that basic science and clinical research that is focused on overcoming the BBB, to optimize delivery to the central nervous system, be identified and supported as a priority topic. For this reason, the third international Cerebrovascular Biology and Blood-Brain Barrier Conference was convened in March 1998 in Gleneden Beach, OR. This meeting brought together basic science and clinical researchers from around the world to analyze BBB function and to discuss delivery of effective agents to the central nervous system for treatment ot brain disease. This report summarizes the information presented at the meeting and the discussions that ensued. The current state of knowledge, obstacles to further understanding the BBB, and research priorities are identified.

Journal

NeurosurgeryOxford University Press

Published: Mar 1, 1999

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