Abstract Context Perfluoroalkyl and polyfluoroalkyl substances (PFASs), a group of ubiquitous environmental chemicals with properties of endocrine disruption, are often detectable in humans. Objective The present study investigated the association between exposure to PFAS and primary ovarian insufficiency (POI). Design, Patients, Interventions and Main Outcome Measures Levels of plasma PFAS were measured in 120 Chinese women with overt POI and 120 healthy controls (2013-2016). Associations between PFAS levels and odds of POI, and hormonal profiles were evaluated using multiple logistic regression and multiple linear regression models. Results Levels of perfluorooctanate (PFOA), perfluorooctane sulfonate (PFOS), and perfluorohexanesulfonate (PFHxS) were positively associated with the risks of POI [highest vs. lowest tertile, PFOA: OR = 3.80 (95% CI: 1.92, 7.49); PFOS: 2.81 (95% CI: 1.46, 5.41); PFHxS: 6.63 (95% CI: 3.22, 13.65)]. In POI patients, levels of PFOS and PFHxS exposure were positively associated with follicle-stimulating hormone [PFOS: adjusted β = 0.26 (95% CI: 0.15, 0.38); PFHxS: 0.16 (95% CI: 0.04, 0.28)] and negatively associated with estradiol [PFOS: -0.30 (95% CI: -0.47, -0.12); PFHxS: -0.19 (95% CI: -0.37, -0.02)]. In addition, the exposure to PFOS and PFOA were associated with elevation of prolactin [PFOS: 0.17 (95% CI: 0.06, 0.29); PFOA: 0.16 (95% CI: 0.01, 0.30)] or decrease of free triiodothyronine [PFOS: -0.88 (95% CI: -1.64, -0.09); PFOA: -0.90 (95% CI: -1.88, 0.09)] and thyroxine [PFOS: -2.99 (95% CI: -4.52, -1.46); PFOA: -3.42 (95% CI: -5.39, -1.46)]. Conclusion High exposure to PFOA, PFOS, and PFHxS is associated with increased risk of POI in human. Clinical trial registration number: 2013-MD-062 Copyright © 2018 Endocrine Society
Journal of Clinical Endocrinology and Metabolism – Oxford University Press
Published: May 4, 2018
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