Association Is Not Causation

Association Is Not Causation TOXICOLOGICAL SCIENCES, 2018, 1–1 doi: 10.1093/toxsci/kfy095 Advance Access Publication Date: April 18, 2018 “The sensitivity of reproductive development to minute Letter to Editor changes caused by BPA exposure.” “The first study to explain the metabolic variation caused by BPA in amino acid.” The study by Khan et al. (2017) is an extremely interesting study The BPA field is controversial enough without introduction on the association of bisphenol A (BPA) levels in children with of a “mechanism of action” for BPA in children that may or may metabolomic profiles, especially as related to steroidogenesis not exist. and amino acid metabolism pathways. However, over 20 times throughout the manuscript the REFERENCES authors use language of causation rather than association. Below are examples from different sections of the paper. Khan, A., Park, H., Lee, H. A., Park, B., Gwak, H. S., Lee, H. R., Jee, S. Abstract: “Are the main targets of perturbation by BPA.” H., and Park, Y. H. (2017). Elevated metabolites of steroido- Introduction: “Understand the mechanistic aspects behind genesis and amino acid metabolism in preadolescent female the effects generated by BPA exposure.” children with high urinary bisphenol A levels: A high resolu- Materials and Methods: “Potential biomarkers related to tion metabolomics study.Toxicol. Sci. 160:371–385. metabolic effects caused by BPA.” Results: “To observe the metabolic alterations caused by BPA David E. Williams in male or female.” “To confirm our hypothesis of sex-related metabolic distur- Linus Pauling Institute, Environmental and Molecular bance caused by BPA.” Toxicology, Oregon State University, Corvallis, Oregon 97331 “Similar to the significant effect caused by high or low BPA To whom correspondence should be addressed. E-mail: david. in children.” williams@oregonstate.edu. “. that sex-related metabolic disturbance caused by BPA.” “. we decided to further investigate additional BPA-induced doi: 10.1093/toxsci/kfy095 metabolic.” Advance Access Publication Date: April 18, 2018 Discussion: “Clarify the possible sex-related metabolic effects caused by BPA exposure.” V C The Author(s) 2018. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com Downloaded from https://academic.oup.com/toxsci/advance-article-abstract/doi/10.1093/toxsci/kfy095/4975769 by Ed 'DeepDyve' Gillespie user on 08 June 2018 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Toxicological Sciences Oxford University Press

Association Is Not Causation

Toxicological Sciences , Volume Advance Article – Apr 18, 2018
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Oxford University Press
Copyright
© The Author(s) 2018. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com
ISSN
1096-6080
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1096-0929
D.O.I.
10.1093/toxsci/kfy095
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Abstract

TOXICOLOGICAL SCIENCES, 2018, 1–1 doi: 10.1093/toxsci/kfy095 Advance Access Publication Date: April 18, 2018 “The sensitivity of reproductive development to minute Letter to Editor changes caused by BPA exposure.” “The first study to explain the metabolic variation caused by BPA in amino acid.” The study by Khan et al. (2017) is an extremely interesting study The BPA field is controversial enough without introduction on the association of bisphenol A (BPA) levels in children with of a “mechanism of action” for BPA in children that may or may metabolomic profiles, especially as related to steroidogenesis not exist. and amino acid metabolism pathways. However, over 20 times throughout the manuscript the REFERENCES authors use language of causation rather than association. Below are examples from different sections of the paper. Khan, A., Park, H., Lee, H. A., Park, B., Gwak, H. S., Lee, H. R., Jee, S. Abstract: “Are the main targets of perturbation by BPA.” H., and Park, Y. H. (2017). Elevated metabolites of steroido- Introduction: “Understand the mechanistic aspects behind genesis and amino acid metabolism in preadolescent female the effects generated by BPA exposure.” children with high urinary bisphenol A levels: A high resolu- Materials and Methods: “Potential biomarkers related to tion metabolomics study.Toxicol. Sci. 160:371–385. metabolic effects caused by BPA.” Results: “To observe the metabolic alterations caused by BPA David E. Williams in male or female.” “To confirm our hypothesis of sex-related metabolic distur- Linus Pauling Institute, Environmental and Molecular bance caused by BPA.” Toxicology, Oregon State University, Corvallis, Oregon 97331 “Similar to the significant effect caused by high or low BPA To whom correspondence should be addressed. E-mail: david. in children.” williams@oregonstate.edu. “. that sex-related metabolic disturbance caused by BPA.” “. we decided to further investigate additional BPA-induced doi: 10.1093/toxsci/kfy095 metabolic.” Advance Access Publication Date: April 18, 2018 Discussion: “Clarify the possible sex-related metabolic effects caused by BPA exposure.” V C The Author(s) 2018. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com Downloaded from https://academic.oup.com/toxsci/advance-article-abstract/doi/10.1093/toxsci/kfy095/4975769 by Ed 'DeepDyve' Gillespie user on 08 June 2018

Journal

Toxicological SciencesOxford University Press

Published: Apr 18, 2018

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