An Exploratory Analysis of Potential New Biomarkers of Cognitive Function

An Exploratory Analysis of Potential New Biomarkers of Cognitive Function Abstract We examined the relationship between serially measured, novel serum biomarkers and a measure of cognitive functioning in older adults. We assayed stored serum samples from two Fels Longitudinal Study visits in N=100 adult participants (visit 1 ages 59.3 + 8.5 years; 53% female), and Montreal Cognitive Assessment (MoCA) scores also assessed at the second visit. Assays included acylcarnitines, amino acids, and 2-hydroxybutyric acid (b-HBA). Cross-sectional correlations between acyclarnitines and amino acids and MoCA were identified. Serial change in short-chain acylcarnitines and Visit 2 MoCA were also correlated. Participants with MoCA scores <26 were more likely to have an increase in short chain acylcarnitines between visit 1 and visit 2 (adjusted O.R. = 5.24; 95% C.I. 1.07-25.9). b-HBA was also correlated with acylcarnitines. Several cross-sectional and serial associations between novel serum biomarkers and cognitive functioning were identified. b-HBA may also be a cost-effective marker of dysregulation associated with cognitive decline. Dementia, Biology of Aging, Epidemiology, Metabolomics © The Author(s) 2018. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/about_us/legal/notices) http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences Oxford University Press

An Exploratory Analysis of Potential New Biomarkers of Cognitive Function

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Publisher
Oxford University Press
Copyright
© The Author(s) 2018. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
ISSN
1079-5006
eISSN
1758-535X
D.O.I.
10.1093/gerona/gly122
Publisher site
See Article on Publisher Site

Abstract

Abstract We examined the relationship between serially measured, novel serum biomarkers and a measure of cognitive functioning in older adults. We assayed stored serum samples from two Fels Longitudinal Study visits in N=100 adult participants (visit 1 ages 59.3 + 8.5 years; 53% female), and Montreal Cognitive Assessment (MoCA) scores also assessed at the second visit. Assays included acylcarnitines, amino acids, and 2-hydroxybutyric acid (b-HBA). Cross-sectional correlations between acyclarnitines and amino acids and MoCA were identified. Serial change in short-chain acylcarnitines and Visit 2 MoCA were also correlated. Participants with MoCA scores <26 were more likely to have an increase in short chain acylcarnitines between visit 1 and visit 2 (adjusted O.R. = 5.24; 95% C.I. 1.07-25.9). b-HBA was also correlated with acylcarnitines. Several cross-sectional and serial associations between novel serum biomarkers and cognitive functioning were identified. b-HBA may also be a cost-effective marker of dysregulation associated with cognitive decline. Dementia, Biology of Aging, Epidemiology, Metabolomics © The Author(s) 2018. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/about_us/legal/notices)

Journal

The Journals of Gerontology Series A: Biomedical Sciences and Medical SciencesOxford University Press

Published: May 26, 2018

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