Abstracts This content is only available as a PDF. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Heart Journal Oxford University Press


European Heart Journal , Volume 22 (Abstract_Supplement) – Sep 1, 2001


Day 2 Sunday, September 2, 2001 Downloaded from https://academic.oup.com/eurheartj/article-abstract/22/Abstract_Supplement/1/466328 by Ed 'DeepDyve' Gillespie user on 04 February 2018 In the third decade of restenosis research: the battle continues 3 IN THE THIRD DECADE OF RESTENOSIS RESEARCH: Results: At the time of abstract submission, 65 subjects were enrolled in the trial and complete follow-up is pending. If no dose-limiting toxicities are encountered, THE BATTLE CONTINUES 90 subjects will be enrolled. There have been no major angiographic or biochemical adverse effects from Antrin PA. The drug appears to be well 99 Modulation of MSS1, a component of the 26S tolerated in all patients except one had a non-dose-related reaction to the infusion, and developed a drug rash requiring antihistamine therapy. A maximum proteasaome, in vascular smooth muscle cells in vitro and following experimental PTCA drug dosage of 4.0 mg/kg was determined. Conclusions: These preliminary results suggest that Antrin PA is a novel, C.F. Townsend, S.E. Francis, J. Chamberlain, J. Gunn, D.C. Grossman, well-tolerated, potential nontraumatic treatment for coronary atherosclerosis. C.M.H Newman. University of Sheffield, Cardiovascular Research Group, Results of the completed enrollment and 30-day safety evaluation will be Sheffield, United Kingdom presented. Background: Vascular smooth muscle cell (VSMC) proliferation and ded- ifferentiation are central features of atherogenesis and restenosis following angioplasty (PTCA). We have previously shown that the expression of MSS1, 101 Local drug delivery of an antitumour lipid A analog inhibits neointimal hyperplasia in dogs a component of the 26S proteasome, is highly dependent upon the differen- tiation and proliferation status of human VSMC in vitro. This study describes M. Fukuta, Iwa, M. Yonezu, Y. Suzuki, Y. Wakida, T. Ota, Y. Ozaki, T. the location of MSS1 protein in human and balloon-injured porcine coronary T. Kobayashi....
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European Heart JournalOxford University Press

Published: Sep 1, 2001

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