Abstracts This content is only available as a PDF. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Heart Journal Oxford University Press


European Heart Journal , Volume 21 (Abstract_Supplement) – Aug 1, 2000


Day 2 Sunday, August 27, 2000 Downloaded from https://academic.oup.com/eurheartj/article-abstract/21/Abstract_Supplement/1/483084 by Ed 'DeepDyve' Gillespie user on 04 February 2018 Gene manipulation in heart failure GENE MANIPULATION IN HEART FAILURE to be appropriate to elicit a therapeutic effect, especially if the transgene codes for a secreted factor that acts through a paracrine mechanism. Preliminary data on gene transfer of an immunomodulatory gene into cardiac allografts will be 132 Morphological and physiological rescue of dilated presented. cardiomyopathy (DCM) by rAAV vector-mediated gene transfer in vivo Transgenic expression of human kallikrein prevents T. Kawada, M. Nakazawa 1 , A. Sakamoto 2 , M. Urabe 3 , Y. Wang 4 , K. Ozawa 3 , haemodynamic alterations and decline in sarcoplasmic T. Toyo-Oka°. Div. of Pharmacy, Niigata Univ. Medical Hospital, 'Dept. of reticulum calcium pump activity in diabetic rats Univ. Niigata, 2 Biotechnology Div., Pharmacology, Niigata School of Medicine, Natl. Cardiovascu. Res. Center, Osaka, 3 Div. Genetic Therap., Jichi Medical C. Tschoepe, R. Vetter', M. Wendorf, M. Koch, F. Spillmann, D. Hauke, School, Tochigi, 4 Dept. Internal Medicine, Univ. of Tokyo, Tokyo, Japan H.P. Schultheiss, M. Bader 2 , T. Walther. Cardiology Dept., Univ. Hospital Benjamin Franklin, I Inst. Pharmacology and Toxicology, Freie Univ. Berlin, Introduction: New treatment of other than cardiac transplantation might be 2 Molecular Medicine, Max-Delbruck Center, Berlin, Germany preferable for the treatment DCM. Hereditary form of idiopathic DCM shares 1/3 in human cases and is a major cause of heart failure Hamsters with the Since kallikrein (KLK), the component of the cardiac kallikrein-kinin system hereditary DCM is suitable for developing gene therapy, because responsible (KKS), which is also located to the sacroplasmatic reticulum (SR) of my- gene encoding delta-sarcoglycan (SG) is deleted in dystrophin-associated gly-...
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European Heart JournalOxford University Press

Published: Aug 1, 2000

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