Abstracts This content is only available as a PDF. © 1996 The European Society of Cardiology http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Heart Journal Oxford University Press


European Heart Journal , Volume 17 (Abstract_Supplement) – Aug 1, 1996


Day 2 Monday, August 26, 1996 Downloaded from https://academic.oup.com/eurheartj/article-abstract/17/Abstract_Supplement/1/596680 by Ed 'DeepDyve' Gillespie user on 04 February 2018 Biology of cardiac overload 3 BIOLOGY OF CARDIAC OVERLOAD 1961 Cardiac hypertrophy modifies repolarization differently in endocardial and epicardial myocytes S.J. Shipsey, S.M. Bryant, G. Hart. Department of Cardiovascular Medicine, /941 Regional differences in mRNA and protein expression . University of Oxford, OX3 9DU, UK pattern of the inhibitory G protein Gio:2 and sarccplasmtc reticulum Ca + ATPase in heart failure due to dilated Hypertrophy is associated with prolongation of action potential duration (APD) cardiomyopathy in ventricular myocytes. In view of endocardial/epicardial differences in APD in guinea pigs, we have studied changes in AP characteristics associated with I.C. Van Gelder 1, M. Flesch, F. Schiffer, P. Schnabel, H.J.G.M. Crijns 1, hypertrophy in these regions. Mild cardiac hypertrophy (HTY) was induced in M. Bohm, University Hospital Cologne, Germany; 1 Thoraxcenter, University guinea pigs by abdominal aortic constriction. Sham operated animals were Hospital Groningen, The Netherlands controls (CON). Myocytes were isolated from basal sub-endocardium (endo) Abnormalities in the if-adrenergic neuroeffector mechanisms and in the intra­ and apical sub-epicardium (epi) of the left ventricular free wall 159 ± 1 days post 2+ cellular Ca handling play a crucial role in the pathogenesis of congestive operation. Membrane voltage was measured using the switch-clamp technique heart failure. Most previous investigations were performed in left ventricular with high resistance microelectrodes (:::::: 20 MQ). Data are expressed as mean (LV) myocardium and conclusions were extrapolated to the ':fail.i~g heart" in ± sem(n), ANOVA was used to assess statistical significance. Hypertrophy was general. The aim was to investigate whether...
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© 1996 The European Society of Cardiology
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This content is only available as a PDF. © 1996 The European Society of Cardiology


European Heart JournalOxford University Press

Published: Aug 1, 1996

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