Abstracts This content is only available as a PDF. © 1997 The European Society of Cardiology http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Heart Journal Oxford University Press


European Heart Journal , Volume 18 (Abstract_Supplement) – Aug 1, 1997


Day 2 Monday, August 25, 1997 Downloaded from https://academic.oup.com/eurheartj/article-abstract/18/Abstract_Supplement/1/515615 by Ed 'DeepDyve' Gillespie user on 04 February 2018 New insights into endothelial function NEW INSIGHTS INTO ENDOTHELIAL FUNCTION 145 Importance of the ACE - polymorphism in endothelium-dependent vasodilation of systemic resistance vessels 143 Laminar shear stress modulates endothelin system expression in human endothelial cells J. Minners, S. Fichtlscherer, S. Dimmeler, S. Ficus, V. Sch2chinger, A.M. Zeiher. Johann Wolfgang Goethe-University, Department of Cardiology, H. Morawietz, A. Schubert, J. Schlüter, M. Szibor, U. ROckschlo8, D. Darmer, Frankfurt, Germany Institute for Pathophysiology, Martin-Luther-University, Halle, J. Holtz. Germany In different risk-factor settings of coronary artery disease (CAD) endothelial vasodilator function is impaired in coronary and systemic arteries, possibly rep- Shear stress acting on the endothelial cells by the blood stream regulates the resenting an early step towards the development of atherosclerosis. Environ- vascular tone and the development and progression of arteriosclerosis. The mental risk-factors and, increasingly, genetic risk-factors have been associated regulation of endothelial genes involved in synthesis and action of endothelin-1 with a reduced endothelial vasodilator function. Thus, we investigated wether by shear stress is studied in less detail. The endothelin synthesis include there is a relation between the ACE-polymorphism and systemic endothelial expression of pre-pro-endothelin-1 (PPET-1), which is subsequently cleaved vasodilator function as evaluated by intraarterial infusion of acetylcholine (ACh) to big-endothelin (38 amino acids). Big-endothelin is processed by endothelin using venous occlusion forearm plethysmography in 36 patients. converting enzyme 1 (ECE-1) to form the active endothelin-1 (21 amino acids). Results: The relative genotype...
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This content is only available as a PDF. © 1997 The European Society of Cardiology


European Heart JournalOxford University Press

Published: Aug 1, 1997

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