SCIENCE TIMES and Fasudil, unlike simvastatin, decreased demonstrated that patients were 1.71 times n = 73) or conscious sedation (CS; the number of multicavernous lesions, more likely to be functional independent n = 77). There was no difference in and improved survival. Further work is at 3 mo if they received endovascular NIHSS in the either group after 24 h. necessary in order to optimize the efficacy therapy. Subgroup meta-analysis of the Forty-one of 47 secondary outcomes were of ROCK inhibition and better define 6 trials with large vessel occlusion (LVO) not significantly different between the 2 pharmacological safety parameters of confirmation demonstrated even better cohorts including overall 3-mo mortality Fasudil administration. functional outcomes. (24.7%). Stratification of modified Rankin These trials have confirmed the signif- scale (mRS) demonstrated improved icant benefit of endovascular therapy functional independence in the GA group Gregory M. Weiner, MD for ischemic stroke patients with LVO. (37.0%) vs CS (18.2%). Hypothermia, AndrewF.Ducruet,MD These studies also highlighted the fact delayed extubation, and pneumonia Department of Neurosurgery that faster recanalization times lead to were all more frequent in the GA University of Pittsburgh improved outcomes. In a recent meta- cohort. Pittsburgh, Pennsylvania analysis of pooled data from
Neurosurgery – Oxford University Press
Published: May 1, 2017
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