A mechanism of nitric oxide regulation in high-altitude Tibetans

A mechanism of nitric oxide regulation in high-altitude Tibetans COMMENTARIES Xu 531 In the paper of He et al. [1], the authors unveiled an impor- assume the blood NOx reflects a local regulation in the lung. The tant mechanism of nitric oxide regulation in Tibetans under only potential risk is that the magnitude of the variance between high-altitude hypoxia, which might be valuable in understand- the blood NOx and the exhaled NO levels could be statistically ing the altitudinal adaption of Tibetan people. In particular, the close to that between populations. authors overturned the previous proposal of a Tibetan-specific Another interesting observation in this paper is the between- NOx up-regulation as an adaptive strategy to high-altitude hy- gender difference at 4802 m—that is, males exhibited a higher poxia and proposed that the NOx up-regulation is probably a NOx level than females at that elevation. In particular, the dif- common physiological response to hypoxia for general popu- ference observed is in the opposite direction compared to a pre- lations, including both Tibetan and Han Chinese. I am con- vious study that reported higher NOx levels in Tibetan females vinced by many lines of evidence presented in the manuscript compared to Tibetan males. As only the sum of nitrate and ni- and I would like to commend the authors for an inspiring trite was measured in this paper, a fair comparative analysis is paper. not applicable at this time. Further study is necessary to resolve One strength of this study is that the authors collected and these incompatible observations. analysed the largest population sample for blood NOx analysis and, in particular, for the first time, Tibetans living at low alti- tude and lowlanders (Han Chinese) living at high altitude were Shuhua Xu analysed. But it is a pity that the NOx data were not available for CAS-MPG Partner Institute for Computational Biology (PICB), Han Chinese above 4500 m. It is possible to collect data from Shanghai Institutes for Biological Sciences, CAS, China those mountaineers from mt. Everest base camp (∼5200 m), of Reviewer of NSR whom many are Han Chinese, although some bias might be in- E-mail: xushua@picb.ac.cn troduced, as they are not permanent residents and they are not random samples. However, according to the study, the elevated NOx level can be maintained for a long period of time in both na- REFERENCE tive Tibetans and lowlanders moving to high altitudes, and ‘the 1. He YX, Qi XB and Ouzhuluobu et al. Natl Sci Rev 2018; 5: 516–29. duration of residence time has no obvious effect on blood NOx level’. I believe the data would be valuable if they are available in the future. National Science Review As the authors also mentioned in the manuscript, they did 5: 531, 2018 not examine the exhaled NO in their population samples. It doi: 10.1093/nsr/nwy040 is reasonable, based on the observation of previous studies, to Advance access publication 28 March 2018 Downloaded from https://academic.oup.com/nsr/article-abstract/5/4/531/4956056 by Ed 'DeepDyve' Gillespie user on 07 August 2018 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png National Science Review Oxford University Press

A mechanism of nitric oxide regulation in high-altitude Tibetans

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Oxford University Press
Copyright
© The Author(s) 2018. Published by Oxford University Press on behalf of China Science Publishing & Media Ltd.
ISSN
2095-5138
eISSN
2053-714X
D.O.I.
10.1093/nsr/nwy040
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Abstract

COMMENTARIES Xu 531 In the paper of He et al. [1], the authors unveiled an impor- assume the blood NOx reflects a local regulation in the lung. The tant mechanism of nitric oxide regulation in Tibetans under only potential risk is that the magnitude of the variance between high-altitude hypoxia, which might be valuable in understand- the blood NOx and the exhaled NO levels could be statistically ing the altitudinal adaption of Tibetan people. In particular, the close to that between populations. authors overturned the previous proposal of a Tibetan-specific Another interesting observation in this paper is the between- NOx up-regulation as an adaptive strategy to high-altitude hy- gender difference at 4802 m—that is, males exhibited a higher poxia and proposed that the NOx up-regulation is probably a NOx level than females at that elevation. In particular, the dif- common physiological response to hypoxia for general popu- ference observed is in the opposite direction compared to a pre- lations, including both Tibetan and Han Chinese. I am con- vious study that reported higher NOx levels in Tibetan females vinced by many lines of evidence presented in the manuscript compared to Tibetan males. As only the sum of nitrate and ni- and I would like to commend the authors for an inspiring trite was measured in this paper, a fair comparative analysis is paper. not applicable at this time. Further study is necessary to resolve One strength of this study is that the authors collected and these incompatible observations. analysed the largest population sample for blood NOx analysis and, in particular, for the first time, Tibetans living at low alti- tude and lowlanders (Han Chinese) living at high altitude were Shuhua Xu analysed. But it is a pity that the NOx data were not available for CAS-MPG Partner Institute for Computational Biology (PICB), Han Chinese above 4500 m. It is possible to collect data from Shanghai Institutes for Biological Sciences, CAS, China those mountaineers from mt. Everest base camp (∼5200 m), of Reviewer of NSR whom many are Han Chinese, although some bias might be in- E-mail: xushua@picb.ac.cn troduced, as they are not permanent residents and they are not random samples. However, according to the study, the elevated NOx level can be maintained for a long period of time in both na- REFERENCE tive Tibetans and lowlanders moving to high altitudes, and ‘the 1. He YX, Qi XB and Ouzhuluobu et al. Natl Sci Rev 2018; 5: 516–29. duration of residence time has no obvious effect on blood NOx level’. I believe the data would be valuable if they are available in the future. National Science Review As the authors also mentioned in the manuscript, they did 5: 531, 2018 not examine the exhaled NO in their population samples. It doi: 10.1093/nsr/nwy040 is reasonable, based on the observation of previous studies, to Advance access publication 28 March 2018 Downloaded from https://academic.oup.com/nsr/article-abstract/5/4/531/4956056 by Ed 'DeepDyve' Gillespie user on 07 August 2018

Journal

National Science ReviewOxford University Press

Published: Jul 1, 2018

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