Abstract CONTEXT Triiodothyronine (T3) is the biologically-active thyroid hormone involved in glucose metabolism. fT3:fT4 ratio, a marker indicating conversion of free thyroxine (fT4) to free T3 (fT3), is also implicated in glucose homeostasis. OBJECTIVE To examine associations of fT3 and fT3:fT4 ratio with gestational diabetes (GDM). DESIGN In a case-control study, thyroid markers (fT3, fT4, TSH) were measured and fT3:fT4 ratio was derived across four visits in pregnancy, including first (gestational weeks 10-14) and second (weeks 15-26) trimester. Conditional logistic regression adjusting for thyroid autoimmunity status and major GDM risk factors estimated trimester-specific associations of thyroid markers with subsequent GDM risk. SETTING 12 U.S. clinical centers PARTICIPANTS 107 GDM cases and 214 non-GDM controls from a multiracial pregnancy cohort of 2,802 women. MAIN OUTCOME MEASURES GDM diagnosis ascertained from medical records RESULTS Both fT3 and fT3:fT4 ratio were positively associated with GDM; aOR (95% CI) comparing the highest vs. lowest fT3 quartile was 4.25 (1.67,10.80) at first and 3.89 (1.50, 10.10) at second trimester. Similarly, the corresponding risk estimates for fT3:fT4 ratio were 8.63 (2.87, 26.00) and 13.60 (3.97, 46.30) at first and second trimester, respectively. Neither TSH nor fT4 was significantly associated with GDM. Isolated hypothyroxinemia in the second, but not first trimester, was significantly related to increased GDM risk; aOR (95% CI) comparing hypothyroxinemic women to euthyroid was 2.97 (1.07,8.24). CONCLUSIONS Higher fT3 levels, potentially resulting from de novo synthesis or increased fT4 to fT3 conversion, may be an indicator of GDM risk starting early in pregnancy. Copyright © 2018 Endocrine Society
Journal of Clinical Endocrinology and Metabolism – Oxford University Press
Published: Jun 7, 2018
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera