A Cerebrospinal Fluid Protein Associated with Moyamoya Disease: Report of Three Cases

A Cerebrospinal Fluid Protein Associated with Moyamoya Disease: Report of Three Cases AbstractOBJECTIVE:The pathogenesis of moyamoya disease is unknown. The purpose of this study was to detect proteins associated with the pathogenesis of moyamoya disease.CLINICAL PRESENTATION:Cerebrospinal fluid (CSF) samples from three patients with moyamoya disease and four control patients who had cervical lesions but no intracranial lesion were studied.INTERVENTION:CSF proteins separated by two-dimensional polyacrylamide gel electrophoresis were analyzed with the SWISS-2DPAGE and SWISS- PROT databases. In the CSF samples from all three patients with moyamoya disease, a polypeptide spot (Mr = 12,000, pi = 5.35) was observed. This spot was not evident in samples from the four control patients and has not been reported in the SWISS-2DPAGE and SWISS-PROT databases.CONCLUSION:A CSF protein, which is possibly novel and associated with moyamoya disease, has been detected. The analysis of CSF by two- dimensional polyacrylamide gel electrophoresis may reveal a clue by which the molecular mechanism of moyamoya disease may be elucidated. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neurosurgery Oxford University Press

A Cerebrospinal Fluid Protein Associated with Moyamoya Disease: Report of Three Cases

A Cerebrospinal Fluid Protein Associated with Moyamoya Disease: Report of Three Cases

170 Graham et al bromatous change. Although the patient Graham et al. report the third re­ regarding the distinction that must be had a cardiac examination with negative ported instance of a primary brain m yx­ made between this lesion and the more results, I would still caution the authors to common meningioma with myxoid de­ oma, an unusual tumor arising from repeat this evaluation in the future. The generation. I would agree that the lesion mesenchymal cells in the convexity pathology is so unusual that one must still is indolent enough as to warrant no fur­ dura of a 16-year-old girl. Histological ther postoperative therapy, although se­ remain vigilant about a possible meta­ differentiation of myxoma from menin­ rial imaging is mandatory. static process. gioma is not difficult, and as the authors M ich ael Salcman point out, there should be no areas of Mitchel S. Berger B a ltim o re , M aryland meningothelial, endotheliomatous, or fi- San Francisco, C a lifo rn ia possible that genetic factors play impor­ A Cerebrospinal Fluid Protein tant roles in its pathogenesis (3, 31, 35). However, the paucity of clinical materi­ Associated with Moyamoya Disease: als for investigation has not allowed a direct resolution of the molecular mech­ Report of Three Cases anism of this disease. Cerebrospinal fluid (CSF), which surrounds intracra­ nial arterial trunks in vivo, has been used to study cerebrovascular diseases Masato Hojo, M.D., Minoru Hoshimaru, M.D., and is one of the few clinical materials Susumu Miyamoto, M.D., Waro Taki, M.D., available for the investigation of the Haruhiko Kikuchi, M.D., Nobuo Hashimoto, M.D. pathogenesis of moyamoya disease (7, Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan 19, 28). Previous studies have revealed that the amount of basic fibroblast growth factor is increased in the CSF of patients with moyamoya disease (32, O BJECTIVE: The pathogenesis of...
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Publisher
Oxford University Press
Copyright
© Published by Oxford University Press.
ISSN
0148-396X
eISSN
1524-4040
D.O.I.
10.1097/00006123-199907000-00040
Publisher site
See Article on Publisher Site

Abstract

AbstractOBJECTIVE:The pathogenesis of moyamoya disease is unknown. The purpose of this study was to detect proteins associated with the pathogenesis of moyamoya disease.CLINICAL PRESENTATION:Cerebrospinal fluid (CSF) samples from three patients with moyamoya disease and four control patients who had cervical lesions but no intracranial lesion were studied.INTERVENTION:CSF proteins separated by two-dimensional polyacrylamide gel electrophoresis were analyzed with the SWISS-2DPAGE and SWISS- PROT databases. In the CSF samples from all three patients with moyamoya disease, a polypeptide spot (Mr = 12,000, pi = 5.35) was observed. This spot was not evident in samples from the four control patients and has not been reported in the SWISS-2DPAGE and SWISS-PROT databases.CONCLUSION:A CSF protein, which is possibly novel and associated with moyamoya disease, has been detected. The analysis of CSF by two- dimensional polyacrylamide gel electrophoresis may reveal a clue by which the molecular mechanism of moyamoya disease may be elucidated.

Journal

NeurosurgeryOxford University Press

Published: Jul 1, 1999

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