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Human genome at ten: Science after the sequence

"With this profound new knowledge, humankind is on the verge of gaining immense, new power to heal. It will revolutionize the diagnosis, prevention and treatment of most, if not all, human diseases." So declared then US President Bill Clinton in the East Room of the White House on 26 June 2000, at an event held to hail the completion of the first draft assemblies of the human genome sequence by two fierce rivals, the publicly funded international Human Genome Project and its private-sector competitor Celera Genomics of Rockville, Maryland (see Nature 405, 983?984; 2000 ). Ten years on, the hoped-for revolution against human disease has not arrived ? and Nature 's poll of more than 1,000 life scientists shows that most don't anticipate that it will for decades to come ( go.nature.com/3Ayuwn ). What the sequence has brought about, however, is a revolution in biology. It has transformed the professional lives of scientists, inspiring them to tackle new biological problems and throwing up some acute new challenges along the way. Almost all biologists surveyed have been influenced in some way by the availability of the human genome sequence. A whopping 69% of those who responded to Nature 's http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Nature Publishing Group (NPG)

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