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positively impacts lifespan [18]. In C . elegans , overexpression of the worm ortholog AAK-2 promotes lifespan extension [19] and AMPK activity is increased under CR conditions [1]. Tissue-specific knock-down ...
. In C . elegans , overexpression of JNK leads to a FOXO-dependent increase in worm lifespan of ∼23-37% ( Oh et al., 2005 ). In flies, FOXO is necessary for the lifespan extension of mutants in which JNK ...
restriction and delay ageing in metazoans . Nature 2004 ; 430 : 686 – 689 . Google Scholar Crossref Search ADS PubMed WorldCat Burnett C et al. Absence of effects of Sir2 overexpression on lifespan in C ...
CrossRef Search ADS PubMed Burnett C Valentini S Cabreiro F et al. ( 2011) Absence of effects of Sir2 overexpression on lifespan in C . elegans and Drosophila. Nature 477: 482– 485. Google Scholar ...
and cellular stress (42). A series of genetic studies has demonstrated that increased Sir2 activity extends the lifespan of (43), as well as the longevity of worms (44) and flies (45). In C . elegans , the ability ...
of bacteria [29–31], and the anti diabetic drug metformin was reported to extend C . elegans lifespan by altering bacterial folate and methionine metabolism [32]. To determine if the effects of captopril ...
in shortened RLS that is similar to the effects of a sir2 ∆ mutant (Bitterman et al., 2002). Overexpressing PNC1 suppresses this inhibition by detoxifying the NAM through deamidation (Gallo et al., 2004 ...
, and loss of mdl-1 has been reported to produce a subtle negative effect on the extension of lifespan in ILS mutants [13]. Download: PPT PowerPoint slide PNG larger image TIFF original image Figure 1. The C ...
and 29% for females (71). However, a recent study (73) by Burnett and colleagues found that dSir2 overexpression did not increase lifespan in Drosophila or the nematode C . elegans when confounds due ...
CrossRef Search ADS PubMed Burnett C Valentini S Cabreiro F et al. ( 2011) Absence of effects of Sir2 overexpression on lifespan in C . elegans and Drosophila. Nature 477: 482– 485. Google Scholar ...
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