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HemoHIM Improves Ovarian Morphology and Decreases Expression of Nerve Growth Factor in Rats with Steroid-Induced Polycystic Ovaries

HemoHIM Improves Ovarian Morphology and Decreases Expression of Nerve Growth Factor in Rats with... Estradiol valerate (EV)-induced polycystic ovaries (PCOs) in rats cause the anovulation and cystic ovarian morphology. We investigated whether treatment with HemoHIM influences the ovarian morphology and the expression of nerve growth factor (NGF) in an EV-induced PCO rat model. PCO was induced by a single intramuscular injection of EV (4 mg, dissolved in sesame oil) in adult cycling rats. HemoHIM was either administered orally (100 mg/kg of body weight/day) for 35 consecutive days or injected intraperitoneally (50 mg/kg of body weight) every other day after EV injection. Ovarian morphology was almost normalized, and NGF was normalized in the PCO + HemoHIM group. HemoHIM lowered the high numbers of antral follicles and increased the number of corpora lutea in PCOs. The results are consistent with a beneficial effect of HemoHIM in the prevention and treatment of PCO syndrome. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Medicinal Food Mary Ann Liebert

HemoHIM Improves Ovarian Morphology and Decreases Expression of Nerve Growth Factor in Rats with Steroid-Induced Polycystic Ovaries

HemoHIM Improves Ovarian Morphology and Decreases Expression of Nerve Growth Factor in Rats with Steroid-Induced Polycystic Ovaries

Journal of Medicinal Food , Volume 12 (6) – Dec 1, 2009

Abstract

Estradiol valerate (EV)-induced polycystic ovaries (PCOs) in rats cause the anovulation and cystic ovarian morphology. We investigated whether treatment with HemoHIM influences the ovarian morphology and the expression of nerve growth factor (NGF) in an EV-induced PCO rat model. PCO was induced by a single intramuscular injection of EV (4 mg, dissolved in sesame oil) in adult cycling rats. HemoHIM was either administered orally (100 mg/kg of body weight/day) for 35 consecutive days or injected intraperitoneally (50 mg/kg of body weight) every other day after EV injection. Ovarian morphology was almost normalized, and NGF was normalized in the PCO + HemoHIM group. HemoHIM lowered the high numbers of antral follicles and increased the number of corpora lutea in PCOs. The results are consistent with a beneficial effect of HemoHIM in the prevention and treatment of PCO syndrome.

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Publisher
Mary Ann Liebert
Copyright
Copyright 2009, Mary Ann Liebert, Inc. and Korean Society of Food Science and Nutrition
Subject
Full Communications
ISSN
1096-620X
eISSN
1557-7600
DOI
10.1089/jmf.2008.1323
pmid
20041792
Publisher site
See Article on Publisher Site

Abstract

Estradiol valerate (EV)-induced polycystic ovaries (PCOs) in rats cause the anovulation and cystic ovarian morphology. We investigated whether treatment with HemoHIM influences the ovarian morphology and the expression of nerve growth factor (NGF) in an EV-induced PCO rat model. PCO was induced by a single intramuscular injection of EV (4 mg, dissolved in sesame oil) in adult cycling rats. HemoHIM was either administered orally (100 mg/kg of body weight/day) for 35 consecutive days or injected intraperitoneally (50 mg/kg of body weight) every other day after EV injection. Ovarian morphology was almost normalized, and NGF was normalized in the PCO + HemoHIM group. HemoHIM lowered the high numbers of antral follicles and increased the number of corpora lutea in PCOs. The results are consistent with a beneficial effect of HemoHIM in the prevention and treatment of PCO syndrome.

Journal

Journal of Medicinal FoodMary Ann Liebert

Published: Dec 1, 2009

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