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. The robustness of this assay authorizes medium throughput screening for cardiosafety purposes and could help to enrich the currently limited Kir2.1 pharmacology. ORIGINAL ARTICLES Electrophysiological ...
studies in an automated patch clamp platform in 384-well format capable of medium throughput screening and profiling studies. We have validated hCav1.2, hCav2.1, hCav2.2, and hCav3.2 channels assays ...
of animals, efficiency and cost.5 The use of a larval zebrafish locomotor assay has also been explored for assessing seizure liability, but this is a medium - throughput assay and misclassifications occur.8 ...
traditional cell and ex vivo models for drug safety assessment. Full and efficient assessment of cardiac liabilities for new drug development is not restricted to electrophysiological analysis of drug effects ...
instruments such as the QPatch were introduced in the 2000s, which provide high throughput , user friendly and high-quality electrophysiological assays [15]). A process that plays a pivotal role in expanding ...
potential is inhibited by its low throughput . Development of a high throughput system for high-content measurements of ratiometric calcium and contractility (sarcomere length) is challenging for 3 reasons ...
techniques clinic between January 2012 and November 2016. PARTICIPANTS/MATERIALS, SETTING, METHODS A HTS assay was developed and validated using intracellular calcium ([Ca2+]i) as a surrogate for motility ...
. Various connections for cells, medium , and pneumatic valve control are included and are filled with dye for visualization. Modified from [46]. (B): A commercial microfluidic platform for high- throughput ...
of electrodes are reviewed in [8], such as metal electrode, glass electrode, voltage and patch clamp, ion selective electrode etc. Another study [9] developed a non-invasive and high- throughput light-induced ...
early in the drug development process. Two criteria should be met: rapid throughput and high predictive rate with few false-positive results. Establishing rapid safety screening requires automation ...
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