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/lp/karger/transmission-of-gb-virus-c-by-blood-transfusions-during-heart-surgery-MoXr30H2Bc
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- Publisher
- Karger
- Copyright
- © 1997 S. Karger AG, Basel
- ISSN
- 0042-9007
- eISSN
- 1423-0410
- DOI
- 10.1159/000461966
- Publisher site
- See Article on Publisher Site
Abstract
AbstractBackground and objectives: Hepatitis-causing viral agents other than those designated A toE are being reported. Their epidemiology, modes of transmission, and infectivity are not yetclear, although they may be transmitted by transfusion. Materials and methods: Thirty fivepatients underwent open-heart surgery, receiving an average of 10.2±10.8 (range 1 to 35) unitsof blood. The patients were investigated postoperatively for the RNA of the putative non-Ato-E hepatitis virus designated as GB virus C (GBV-C). Results: Four patients (12%) acquiredGBV-C RNA in the serum within 2 to 4 weeks after the operation. GBV-C RNA was detected inat least one of the blood units received by three patients, all of whose units were available fortesting, with a sequence in the nonstructural 3 region identical to that from the correspondingpatient. Three patients developed elevated alanine aminotransferase levels which persisted fortwo weeks or longer in two of them. Conclusions: GBV-C is transmissible by transfusion andcan induce elevated transaminase levels.
Journal
Vox Sanguinis – Karger
Published: Jan 1, 2017