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- Publisher
- Karger
- Copyright
- © 2013 S. Karger AG, Basel
- ISSN
- 1660-2854
- eISSN
- 1660-2862
- DOI
- 10.1159/000355261
- Publisher site
- See Article on Publisher Site
Abstract
Alzheimer's disease (AD) is an irreversible neurodegenerative disease, still lacking proper clinical treatment. Therefore, many researchers have focused on the possibility of therapeutic use of stem cells for AD. Adipose-derived stem cells (ASCs), mesenchymal stem cells (MSCs) isolated from adipose tissue, are well known for their pluripotency and their ability to differentiate into multiple tissue types and have immune modulatory properties similar to those of MSCs from other origins. Because of their biological properties, ASCs can be considered for cell therapy and neuroregeneration. Our recent results clearly showed the therapeutic potential of these cells after transplantation into Tg2576 mice (an AD mouse model). Intravenously or intracerebrally transplanted human ASCs (hASCs) greatly improved the memory impairment and the neuropathology, suggesting that hASCs have a high therapeutic potential for AD.
Journal
Neurodegenerative Diseases – Karger
Published: Jan 1, 2013
Keywords: Adipose-derived stem cells; Alzheimer’s disease