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The Role of Endothelium in Leukocytes Emigration: The Views of Cohnheim, Metchnikoff and Their Contemporaries

The Role of Endothelium in Leukocytes Emigration: The Views of Cohnheim, Metchnikoff and Their... History of Pathology © 1989 S. Karger AG, Basel Pathol Im munopathol Res 1989;8:35-41 0257-2761/89/0081-0035S2.7S/0 The Role of Endothelium in Leukocytes Emigration: The Views of Cohnheim, Metchnikoff and Their Contemporaries Henry Z. Movat Departments of Pathology and of Immunology, University of Toronto, Medical Sciences Building, Toronto, Ont., Canada There are 3 or 4 events in leukocyte emi­ presumably emigration, by rendering endo­ gration: (a) vasomotor changes; (b) adhesion thelial cells hyperadhesive for leukocytes. of the leukocytes to the endothelial lining of Thus two mechanisms of leukocyte emigra­ postcapillary and larger venules; (c) emigra­ tion have been proposed: one leukocyte-de­ tion through the vessel wall, and (d) migra­ pendent (induced by chemotaxins and not tion to the inflammatory focus, presumably dependent on protein synthesis) and another along a chemotactic gradient. How deep into endothelial-dependent (induced by endo­ the vessel chemotaxins reach from the site of toxin or interleukin 1 and protein synthesis- their generation in the tissue is uncertain. dependent) [reviewed by Bevilacqua et al., Some investigators believe, based on in vitro 1987b; Harlan et al., 1987]. In vivo observa­ observations, that in vivo as well chemotax­ tions partially support this concept [Me ins may reach the leukocytes in the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pathology and Immunopathology Research Karger

The Role of Endothelium in Leukocytes Emigration: The Views of Cohnheim, Metchnikoff and Their Contemporaries

Movat, Henry Z.
Pathology and Immunopathology Research , Volume 8 (1): 7 – Jan 1, 1989
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Publisher
Karger
Copyright
© 1989 S. Karger AG, Basel
ISSN
0257-2761
eISSN
2235-1655
DOI
10.1159/000157136
Publisher site
See Article on Publisher Site

Abstract

History of Pathology © 1989 S. Karger AG, Basel Pathol Im munopathol Res 1989;8:35-41 0257-2761/89/0081-0035S2.7S/0 The Role of Endothelium in Leukocytes Emigration: The Views of Cohnheim, Metchnikoff and Their Contemporaries Henry Z. Movat Departments of Pathology and of Immunology, University of Toronto, Medical Sciences Building, Toronto, Ont., Canada There are 3 or 4 events in leukocyte emi­ presumably emigration, by rendering endo­ gration: (a) vasomotor changes; (b) adhesion thelial cells hyperadhesive for leukocytes. of the leukocytes to the endothelial lining of Thus two mechanisms of leukocyte emigra­ postcapillary and larger venules; (c) emigra­ tion have been proposed: one leukocyte-de­ tion through the vessel wall, and (d) migra­ pendent (induced by chemotaxins and not tion to the inflammatory focus, presumably dependent on protein synthesis) and another along a chemotactic gradient. How deep into endothelial-dependent (induced by endo­ the vessel chemotaxins reach from the site of toxin or interleukin 1 and protein synthesis- their generation in the tissue is uncertain. dependent) [reviewed by Bevilacqua et al., Some investigators believe, based on in vitro 1987b; Harlan et al., 1987]. In vivo observa­ observations, that in vivo as well chemotax­ tions partially support this concept [Me ins may reach the leukocytes in the

Journal

Pathology and Immunopathology Research – Karger

Published: Jan 1, 1989

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