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/lp/karger/the-neonatal-development-of-rat-liver-l-homoserine-dehydratase-5L6uF223fn
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- Publisher
- Karger
- Copyright
- © 1972 S. Karger AG, Basel
- ISSN
- 0013-9432
- eISSN
- 2504-2564
- DOI
- 10.1159/000459478
- Publisher site
- See Article on Publisher Site
Abstract
Homoserine dehydratase activity is a measureof cystathionase, an enzyme which catalyses the last stepleading to cysteine formation in the transsulphuration pathway.The enzyme develops rapidly in fetal rat liver startingon the 20th day of gestation and reaches its adult level on the2nd day after birth. It cannot be prematurely induced bytreatment of fetal animals with glucagon, hydrocortisone orthyroxine, which are effective in elevating other enzymes inthe same experiments. Glucagon treatment significantlyraised the enzyme level in 30-day-old rats. With the prenatal development of this enzyme,all three enzymes for the conversion of methionine to cysteine are functional in rat liverat the time of birth, so that cysteine cannot be an essential amino acid in the infant rat ashas been suggested for the human infant.
Journal
Enzyme – Karger
Published: Jan 1, 2017
Keywords: Transsulphuration; Neonatal development; Hormonal effects; Rat liver; L-Homoserine dehydratase; Cystathionase; Cysteine