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The Development of Pernicious Anaemia

The Development of Pernicious Anaemia Proc. 7th Congr. europ. Soc. Haemat., London 1959; Acta haemat. 24: 1-6 (1960). i T h e D e v e lo p m e n t o f P e rn ic io u s A n ae m ia L e s l i e J . W it t s Nuffield Department of Medicine, Radclifie Infirmary, Oxford Pernicious anaemia in the adult can be defined as a megaloblastic anaem ia associated with avitaminosis B12, due to defective absorption of the vitam in, which absorption can be restored to normal by the administration of intrinsic factor. This defect is associated with an irreversible degeneration of the gastric mucosa. It is obvious th at such a disease cannot appear suddenly and completely, as M inerva sprang fully armed from the head of Jove, for both the degeneration o f the gastric mucosa and the exhaustion of the supplies of vitamin B 12 must take some time, an d today I want to address myself briefly to the question o f what we know a b o u t the early stages of pernicious anaemia. Before entertaining the diagnosis of pernicious anaemia it is essential to know that the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Haematologica Karger

The Development of Pernicious Anaemia

Witts, Leslie J.
Acta Haematologica , Volume 24 (1-3): 6 – Jan 1, 2009
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Publisher
Karger
Copyright
© 1960 S. Karger AG, Basel
ISSN
0001-5792
eISSN
1421-9662
DOI
10.1159/000206434
Publisher site
See Article on Publisher Site

Abstract

Proc. 7th Congr. europ. Soc. Haemat., London 1959; Acta haemat. 24: 1-6 (1960). i T h e D e v e lo p m e n t o f P e rn ic io u s A n ae m ia L e s l i e J . W it t s Nuffield Department of Medicine, Radclifie Infirmary, Oxford Pernicious anaemia in the adult can be defined as a megaloblastic anaem ia associated with avitaminosis B12, due to defective absorption of the vitam in, which absorption can be restored to normal by the administration of intrinsic factor. This defect is associated with an irreversible degeneration of the gastric mucosa. It is obvious th at such a disease cannot appear suddenly and completely, as M inerva sprang fully armed from the head of Jove, for both the degeneration o f the gastric mucosa and the exhaustion of the supplies of vitamin B 12 must take some time, an d today I want to address myself briefly to the question o f what we know a b o u t the early stages of pernicious anaemia. Before entertaining the diagnosis of pernicious anaemia it is essential to know that the

Journal

Acta Haematologica – Karger

Published: Jan 1, 2009

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