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Sugar Receptors of Different Types in Human Metastases to Lung and Liver

Sugar Receptors of Different Types in Human Metastases to Lung and Liver Endogenous sugar receptors of human tumors, supposedly involved in recogni-tive interactions and growth regulation, were comparatively analyzed from human metastases to lung and liver by affinity chromatography and subsequent sodium dodecyl sulfate-polyacrylamide gel electrophoresis. These profiles of sugar receptors including Ca<sup>2+</sup>-depen-dent and Ca<sup>2+</sup>-independent specificities to α- and β-galactosides, α-mannosyl and α-fucosyl moieties from salt and detergent extracts were found to be significantly different from the profile of the corresponding normal tissue. Metastatic lesions to lung from three different types of primary tumors revealed primarily tumor-associated mannan- and galactoside-binding proteins, whereas different liver metastases showed a tendency towards preferential expression of additional β-galactoside-binding proteins and, to a reduced extent, fucose-binding proteins. The patterns of two metastatic lesions to lung and liver from a similar primary tumor, a colon carcinoma, disclose significant differences. Each resembles the pattern of other metastases to the same target organ more than it resembles the pattern of metastatic lesions to the other target organ, derived from a similar primary tumor. Further analyses of two primary liver tumors underscore the significance of changes in such a pattern upon malignant transformation. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Tumor Biology Karger

Sugar Receptors of Different Types in Human Metastases to Lung and Liver

Gabius, Hans-Joachim; Engelhardt, Reinhild
Tumor Biology , Volume 9 (1): 16 – Jan 1, 1988
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Publisher
Karger
Copyright
© 1988 S. Karger AG, Basel
ISSN
1010-4283
eISSN
1423-0380
DOI
10.1159/000217542
Publisher site
See Article on Publisher Site

Abstract

Endogenous sugar receptors of human tumors, supposedly involved in recogni-tive interactions and growth regulation, were comparatively analyzed from human metastases to lung and liver by affinity chromatography and subsequent sodium dodecyl sulfate-polyacrylamide gel electrophoresis. These profiles of sugar receptors including Ca<sup>2+</sup>-depen-dent and Ca<sup>2+</sup>-independent specificities to α- and β-galactosides, α-mannosyl and α-fucosyl moieties from salt and detergent extracts were found to be significantly different from the profile of the corresponding normal tissue. Metastatic lesions to lung from three different types of primary tumors revealed primarily tumor-associated mannan- and galactoside-binding proteins, whereas different liver metastases showed a tendency towards preferential expression of additional β-galactoside-binding proteins and, to a reduced extent, fucose-binding proteins. The patterns of two metastatic lesions to lung and liver from a similar primary tumor, a colon carcinoma, disclose significant differences. Each resembles the pattern of other metastases to the same target organ more than it resembles the pattern of metastatic lesions to the other target organ, derived from a similar primary tumor. Further analyses of two primary liver tumors underscore the significance of changes in such a pattern upon malignant transformation.

Journal

Tumor Biology – Karger

Published: Jan 1, 1988

Keywords: Lectin; Metastases; Sugar receptor; Malignancy

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