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- Publisher
- Karger
- Copyright
- © 2001 S. Karger AG, Basel and IAP
- ISSN
- 1424-3903
- eISSN
- 1424-3911
- DOI
- 10.1159/000055847
- Publisher site
- See Article on Publisher Site
Abstract
Mutations in the gene encoding for the pancreatic secretory trypsin inhibitor or serine protease inhibitor, Kazal type I (SPINK1) have been associated with different entities of chronic pancreatitis. While there is no doubt about the involvement of SPINK1 mutations in pancreatic inflammatory disease, much controversy has arisen regarding which alterations are associated with disease and what type of disease model should be applied when the SPINK1 gene is examined. This article presents the existing data on SPINK1 mutations in idiopathic chronic pancreatitis, familial pancreatitis, hereditary pancreatitis and tropical pancreatitis. The possible role of SPINK1 mutations and polymorphisms in pancreatic disease is discussed.
Journal
Pancreatology – Karger
Published: Jan 1, 2001
Keywords: Serine protease; Hereditary pancreatitis; Tropical pancreatitis; Idiopathic pancreatitis; Chronic pancreatitis