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Skeletal Muscle Performance in Adults with Growth Hormone Deficiency

Skeletal Muscle Performance in Adults with Growth Hormone Deficiency Skeletal muscle mass and function were assessed in 24 adults (16 males, 8 females) with severe, longstanding GH deficiency. Compared to 41 untrained controls (26 males, 15 females), adults with GH deficiency had reduced cross-sectional area of thigh muscle/body weight (p = 0.01), reduced quadriceps force/weight (males: p = 0.002; females: p < 0.0001), and reduced quadriceps force/muscle area (males: p = 0.005). This suggests (a) that adults with GH deficiency have reduced skeletal muscle mass due, in part, to the absence of the anabolic effects of GH, and (b) that skeletal muscle force may be reduced due to altered muscle mass, contractile elements/muscle fibre, anaerobic energy supply, neural recruitment of fibres, or a combination of these. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Hormone Research in Paediatrics Karger

Skeletal Muscle Performance in Adults with Growth Hormone Deficiency

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Publisher
Karger
Copyright
© 1990 S. Karger AG, Basel
ISSN
1663-2818
eISSN
1663-2826
DOI
10.1159/000181585
Publisher site
See Article on Publisher Site

Abstract

Skeletal muscle mass and function were assessed in 24 adults (16 males, 8 females) with severe, longstanding GH deficiency. Compared to 41 untrained controls (26 males, 15 females), adults with GH deficiency had reduced cross-sectional area of thigh muscle/body weight (p = 0.01), reduced quadriceps force/weight (males: p = 0.002; females: p < 0.0001), and reduced quadriceps force/muscle area (males: p = 0.005). This suggests (a) that adults with GH deficiency have reduced skeletal muscle mass due, in part, to the absence of the anabolic effects of GH, and (b) that skeletal muscle force may be reduced due to altered muscle mass, contractile elements/muscle fibre, anaerobic energy supply, neural recruitment of fibres, or a combination of these.

Journal

Hormone Research in Paediatrics – Karger

Published: Jan 1, 1990

Keywords: Lean body mass; Skeletal muscle; Somatotropin; Strength; Insulin-like growth factor 1

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