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/lp/karger/role-of-serine-threonine-protein-phosphatase-in-alzheimer-s-disease-2sKkjloqVq
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- Publisher
- Karger
- Copyright
- © 2003 S. Karger AG, Basel
- ISSN
- 1424-862X
- eISSN
- 1424-8638
- DOI
- 10.1159/000067425
- Publisher site
- See Article on Publisher Site
Abstract
Accumulating evidence indicates that serine/threonine (Ser/Thr) protein phosphatases (PPs), such as PP1, PP2A and PP2B, participate in the neurodegenerative progress in Alzheimer’s disease (AD). The general characteristics and pathologic changes of PP1, PP2A and PP2B in AD, and their relations with microtubule-associated proteins, focusing mainly on τ protein, neurofilament (NF), amyloid precursor protein (APP) processing and synaptic plasticity are discussed. Deriving novel insight into the particular topic will attract greater attention to more active investigation and effective therapeutic intervention in the future.
Journal
Neurosignals – Karger
Published: Jan 1, 2003
Keywords: Serine/threonine protein phosphatase; Alzheimer’s disease; τ protein; Neurofilament