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Report of a WHO Scientific Group Select Bibliography (Part 4 of 4)

Report of a WHO Scientific Group Select Bibliography (Part 4 of 4) G8 Factors Regulating the Immune Response type has been defined as a central failure of responsiveness brought about by exposure to antigen, immunologically competent cells becoming unable to initiate synthesis of a restricted range of antibodies (or comparable recognition units for cellular immunity). An essential feature of this definition is central failure, cells becoming unable to respond; there is no failure of antigen to react them (afferent block) or secretion of a product that is subsequently blocked (efferent block). Another essential feature is specificity, for only a restricted range of capabilities are lost; this is in contrast to the non-specific unrespon- sivencss that can be produced with radiation or immunosuppressive drugs. Unresponsiveness induced by antigen is of direct interest because of the hope that the induction of tolerance will in the future aid organ transplantation. It is also to be hoped that study of the termination of tolerance will reveal autoimmune disease mechanisms. In addition, tolerance touches on many points of fundamental immunological interest. 8.7.1 Induction of Tolerance Susceptibility to the induction of immunological paralysis is ap­ parently not a restricted property of immunologically competent cells, found only under special circumstances. On the contrary, susceptibility to the induction of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Archives of Allergy and Immunology Karger

Report of a WHO Scientific Group Select Bibliography (Part 4 of 4)

International Archives of Allergy and Immunology , Volume 38 (Suppl 1): 21 – Jan 1, 1970
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Publisher
Karger
Copyright
© 1970 S. Karger AG, Basel
ISSN
1018-2438
eISSN
1423-0097
DOI
10.1159/000316218
Publisher site
See Article on Publisher Site

Abstract

G8 Factors Regulating the Immune Response type has been defined as a central failure of responsiveness brought about by exposure to antigen, immunologically competent cells becoming unable to initiate synthesis of a restricted range of antibodies (or comparable recognition units for cellular immunity). An essential feature of this definition is central failure, cells becoming unable to respond; there is no failure of antigen to react them (afferent block) or secretion of a product that is subsequently blocked (efferent block). Another essential feature is specificity, for only a restricted range of capabilities are lost; this is in contrast to the non-specific unrespon- sivencss that can be produced with radiation or immunosuppressive drugs. Unresponsiveness induced by antigen is of direct interest because of the hope that the induction of tolerance will in the future aid organ transplantation. It is also to be hoped that study of the termination of tolerance will reveal autoimmune disease mechanisms. In addition, tolerance touches on many points of fundamental immunological interest. 8.7.1 Induction of Tolerance Susceptibility to the induction of immunological paralysis is ap­ parently not a restricted property of immunologically competent cells, found only under special circumstances. On the contrary, susceptibility to the induction of

Journal

International Archives of Allergy and Immunology – Karger

Published: Jan 1, 1970

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