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- Publisher
- Karger
- Copyright
- © 2001 S. Karger AG, Basel
- ISSN
- 0378-7346
- eISSN
- 1423-002X
- DOI
- 10.1159/000052987
- Publisher site
- See Article on Publisher Site
Abstract
The aim of this study was to investigate the relationship between plasma endothelin 1 (ET-1) levels and T helper (Th)-1:Th2 cell immunity in women with preeclampsia. The percentage of Th1 and Th2 cells and the Th1:Th2 cell ratios in peripheral blood from 11 normal pregnant women and 11 patients with preeclampsia at 29–34 weeks of gestation were calculated using flow cytometry. The plasma ET-1 level was also determined using a modified radioimmunoassay. The plasma ET-1 concentrations and the Th1:Th2 cell ratios in normal pregnancies were significantly lower than those in patients with preeclampsia. Negative correlations were found between plasma ET-1 levels and Th2 cells in both the preeclamptic pregnancy groups and in the normal pregnant women. Our results indicate that elevated ET-1 levels are associated with a Th1:Th2 imbalance in preeclampsia.
Journal
Gynecologic and Obstetric Investigation – Karger
Published: Nov 1, 2001
Keywords: Endothelin 1; Th1; Th2; Preeclampsia