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Recent Clinical and Immunological Aspects of Penicillin Allergy (Part 2 of 2)

Recent Clinical and Immunological Aspects of Penicillin Allergy (Part 2 of 2) and Immunological Aspects of Penicillin Allergy 239 Fractionation and ultracentrifugation studies have indicated th at at least two types o f antibodies may be responsible for the hem­ agglutination reactions observed in hum an sera (22, 50, 59). T he most frequently encountered antibody is a 19 S macroglobulin with y 1 electrophoretic mobility. This IgM antibody may be present even in patients treated with PN w ithout any apparent allergic reaction. It does not seem to transfer PPL or PN skin hypersensitivity to guinea-pigs (50, 16), m an (16) or monkeys (16). Its pathogenic significance is therefore questionable and it might possibly be con­ sidered as analogous to the ‘blocking’ antibodies appearing in the sera of allergic and normal individuals upon injection with pollen allergens. Another hem agglutinating antibody to be less frequently en­ countered is a 7 S y globulin with y 2 electrophoretic mobility. The relationship of this antibody w’ith PN allergy and its ability to trans­ fer PPL skin hypersensitivity have not yet been sufficiently investi­ gated. Finally, antibodies ofreaginic type responsible for the transfer of PPL skin hypersensitivity may be separated from the macroglobu­ lin hemagglutinating hum an anti-PN C O yl antibodies (16). http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Archives of Allergy and Immunology Karger

Recent Clinical and Immunological Aspects of Penicillin Allergy (Part 2 of 2)

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Publisher
Karger
Copyright
© 1965 S. Karger AG, Basel
ISSN
1018-2438
eISSN
1423-0097
DOI
10.1159/000316029
Publisher site
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Abstract

and Immunological Aspects of Penicillin Allergy 239 Fractionation and ultracentrifugation studies have indicated th at at least two types o f antibodies may be responsible for the hem­ agglutination reactions observed in hum an sera (22, 50, 59). T he most frequently encountered antibody is a 19 S macroglobulin with y 1 electrophoretic mobility. This IgM antibody may be present even in patients treated with PN w ithout any apparent allergic reaction. It does not seem to transfer PPL or PN skin hypersensitivity to guinea-pigs (50, 16), m an (16) or monkeys (16). Its pathogenic significance is therefore questionable and it might possibly be con­ sidered as analogous to the ‘blocking’ antibodies appearing in the sera of allergic and normal individuals upon injection with pollen allergens. Another hem agglutinating antibody to be less frequently en­ countered is a 7 S y globulin with y 2 electrophoretic mobility. The relationship of this antibody w’ith PN allergy and its ability to trans­ fer PPL skin hypersensitivity have not yet been sufficiently investi­ gated. Finally, antibodies ofreaginic type responsible for the transfer of PPL skin hypersensitivity may be separated from the macroglobu­ lin hemagglutinating hum an anti-PN C O yl antibodies (16).

Journal

International Archives of Allergy and Immunology – Karger

Published: Jan 1, 2010

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