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Pregnancy Effects on Nonhuman Primate High Density Lipoproteins

Pregnancy Effects on Nonhuman Primate High Density Lipoproteins The concentration of cholesterol in high density lipoproteins (HDL) hasbeen shown to be dramatically decreased during pregnancy in Macaca nemestrina. HDLwere isolated from females of this species at various stages of pregnancy to determine ifpregnancy also alters their composition and size. The chemical compositions of the HDLwere determined and found different in pregnant animals; the mass ratio of surface (coat) tocenter (core) constituents was higher, suggesting that the average size of HDL decreasedduring pregnancy. When measured chromatographically, the average size of HDL wasfound to decrease during pregnancy. This change in HDL size was accompanied by a minoralteration in apolipoprotein distribution. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Medical Primatology Karger

Pregnancy Effects on Nonhuman Primate High Density Lipoproteins

Journal of Medical Primatology , Volume 10 (1): 10 – Jan 1, 2017

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References (11)

Publisher
Karger
Copyright
© 1981 S. Karger AG, Basel
ISSN
0047-2565
eISSN
1600-0684
DOI
10.1159/000460047
Publisher site
See Article on Publisher Site

Abstract

The concentration of cholesterol in high density lipoproteins (HDL) hasbeen shown to be dramatically decreased during pregnancy in Macaca nemestrina. HDLwere isolated from females of this species at various stages of pregnancy to determine ifpregnancy also alters their composition and size. The chemical compositions of the HDLwere determined and found different in pregnant animals; the mass ratio of surface (coat) tocenter (core) constituents was higher, suggesting that the average size of HDL decreasedduring pregnancy. When measured chromatographically, the average size of HDL wasfound to decrease during pregnancy. This change in HDL size was accompanied by a minoralteration in apolipoprotein distribution.

Journal

Journal of Medical PrimatologyKarger

Published: Jan 1, 2017

Keywords: Lipoproteins; Pregnancy; Cholesterol

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