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The concentration of cholesterol in high density lipoproteins (HDL) hasbeen shown to be dramatically decreased during pregnancy in Macaca nemestrina. HDLwere isolated from females of this species at various stages of pregnancy to determine ifpregnancy also alters their composition and size. The chemical compositions of the HDLwere determined and found different in pregnant animals; the mass ratio of surface (coat) tocenter (core) constituents was higher, suggesting that the average size of HDL decreasedduring pregnancy. When measured chromatographically, the average size of HDL wasfound to decrease during pregnancy. This change in HDL size was accompanied by a minoralteration in apolipoprotein distribution.
Journal of Medical Primatology – Karger
Published: Jan 1, 2017
Keywords: Lipoproteins; Pregnancy; Cholesterol
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