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Case Reports Potential Sampling Error in Fine Needle Aspiration Biopsy of Dedifferentiated Chondrosarcoma A Report of 4 Cases Allen C. Rinas, M.S., C.T.(ASCP), C.M.I.A.C., William G. Ward, M.D., and Scott E. Kilpatrick, M.D. Background containing a spindled to polygonal, nonspecific, pleomorphic Dedifferentiated chondrosarcoma is a rare, poorly under- sarcoma unaccompanied by definite matrix material; 1 of stood and often fatal sarcoma that usually manifests as a these had a concomitant core needle biopsy (CNB), also high grade, non–cartilage-producing sarcoma juxtaposed demonstrating pleomorphic sarcoma. The third primary cy- against a low grade chondrosarcoma. A correct diagnosis re- tologic specimen revealed low grade chondrosarcoma, but a quires recognition of both com- concomitant CNB showed only ponents. In the absence of com- a high grade, non–matrix- plete resection, rendering a producing sarcoma. The last Due to sampling error, the specific diagnosis on small patient developed a metastasis diagnosis of dedifferentiated biopsy specimens, such as fine to the opposite femur; FNAB needle aspiration biopsy revealed a high grade spindle chondrosarcoma may be difficult (FNAB), may be extraordi- cell sarcoma. In none of the (if not impossible) to establish by narily difficult. FNAB or CNB specimens were both low and high grade cytologic examination
Acta Cytologica – Karger
Published: Jan 1, 2011
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