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Platelet Lysosomal Enzymes Are Normal in Myeloproliferative Disorders

Platelet Lysosomal Enzymes Are Normal in Myeloproliferative Disorders In platelets of subjects affected with myeloproliferative disorders the following lysosomal enzymes were studied: α-mannosidase, α-fucosidase, β-galactosidase, β-glucosidase, β-glucuronidase, β-N-acetylglucosaminidase and acid phosphatase. For each enzyme the specific activity, the optimum of pH and buffer, K<sub>m</sub> and saturating substrate concentrations, as well as thermostability were determined. Control and patient enzymes showed no difference. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Haematologica Karger

Platelet Lysosomal Enzymes Are Normal in Myeloproliferative Disorders

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Publisher
Karger
Copyright
© 1984 S. Karger AG, Basel
ISSN
0001-5792
eISSN
1421-9662
DOI
10.1159/000206385
Publisher site
See Article on Publisher Site

Abstract

In platelets of subjects affected with myeloproliferative disorders the following lysosomal enzymes were studied: α-mannosidase, α-fucosidase, β-galactosidase, β-glucosidase, β-glucuronidase, β-N-acetylglucosaminidase and acid phosphatase. For each enzyme the specific activity, the optimum of pH and buffer, K<sub>m</sub> and saturating substrate concentrations, as well as thermostability were determined. Control and patient enzymes showed no difference.

Journal

Acta Haematologica – Karger

Published: Jan 1, 1984

Keywords: Glycosidases; Lysosomes; Myeloproliferative disorders; Platelets

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