Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Platelet aggregation in diabetic Nigerians

Platelet aggregation in diabetic Nigerians The prevalence of macrovascular thrombosis among African diabetic patients has been shown to be lower than in Caucasians.Differences in platelet aggregation may be responsible for this observation. There has been no previous study of plateletaggregation among type-2 diabetic Nigerians. The aim of this study was to investigate platelet aggregation among diabeticNigerian patients. Platelets from 34 diabetic patients (24 males, 10 females) and 35 control subjects were studied foraggregation in response to adenosine, ADP, and adrenaline. The intensity of the aggregation was categorized as excellent(>80%), moderate (30% - 79%), and poor (<30%). Diabetic and control subjects were of similar age, and had similar plateletcounts and serum antithrombin III levels. Similarly, both diabetic patients and control subjects demonstrated lower plateletaggregation to collagen, ADP and adrenaline. However, while all control subjects exhibited spontaneous disaggregation withADP, this was not seen in 14% of the diabetic patients (P<0.05). In diabetic Nigerians, although there is increased tendencyto impaired platelet disaggregation, platelet hyper-aggregability is uncommon and this may be one of the reasons for theobserved low incidence of large vessel disease, especially coronary artery disease, in our patients. ( Int J Diab Metab14: 33-37, 2006) http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Dubai Diabetes and Endocrinology Journal Karger

Platelet aggregation in diabetic Nigerians

Download PDF
5 pages

Loading next page...
 
/lp/karger/platelet-aggregation-in-diabetic-nigerians-5PZU7NUaKb

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
Karger
Copyright
© 2019 S. Karger AG, Basel
ISSN
2673-1797
eISSN
2673-1738
DOI
10.1159/000497590
Publisher site
See Article on Publisher Site

Abstract

The prevalence of macrovascular thrombosis among African diabetic patients has been shown to be lower than in Caucasians.Differences in platelet aggregation may be responsible for this observation. There has been no previous study of plateletaggregation among type-2 diabetic Nigerians. The aim of this study was to investigate platelet aggregation among diabeticNigerian patients. Platelets from 34 diabetic patients (24 males, 10 females) and 35 control subjects were studied foraggregation in response to adenosine, ADP, and adrenaline. The intensity of the aggregation was categorized as excellent(>80%), moderate (30% - 79%), and poor (<30%). Diabetic and control subjects were of similar age, and had similar plateletcounts and serum antithrombin III levels. Similarly, both diabetic patients and control subjects demonstrated lower plateletaggregation to collagen, ADP and adrenaline. However, while all control subjects exhibited spontaneous disaggregation withADP, this was not seen in 14% of the diabetic patients (P<0.05). In diabetic Nigerians, although there is increased tendencyto impaired platelet disaggregation, platelet hyper-aggregability is uncommon and this may be one of the reasons for theobserved low incidence of large vessel disease, especially coronary artery disease, in our patients. ( Int J Diab Metab14: 33-37, 2006)

Journal

Dubai Diabetes and Endocrinology Journal – Karger

Published: Jan 1, 2019

Keywords: diabetes mellitus; platelet aggregation; large vessel disease; Nigerians

There are no references for this article.