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/lp/karger/patients-with-cll-and-hypocomplementaemia-have-an-impaired-serum-B1fjBoYpy0
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- Publisher
- Karger
- Copyright
- © 1988 S. Karger AG, Basel
- ISSN
- 0253-5076
- eISSN
- 2504-2424
- DOI
- 10.1159/000463030
- Publisher site
- See Article on Publisher Site
Abstract
The bactericidal effect of 25 serum samples from 23 patients with chronic lymphocytic leukaemia (CLL) against the Salmonella minnesota S form and Re mutant has been studied. No killing of the S form was observed in any of the sera tested, whereas a normal bactericidal effect was found against the Re mutant (group 1) in 17/25 sera of CLL patients. By contrast, in 8 serum samples from 6 CLL patients no killing or a markedly delayed killing of the Re strain was observed (group 2). Significant differences in the complement levels were found between the sera of group 1 and group 2. In group 1 mostly normal or elevated complement levels were observed, while in group 2 levels of C4 and C2 were found to be strongly decreased. A significant correlation was found between the bactericidal effect on the one hand and the C4 and C2 levels on the other.
Journal
Complement – Karger
Published: Jan 1, 2017
Keywords: Complement; Bacteria; Leukemia; Chronic lymphocytic leukaemia; Bacterium killing; Serum-sensitive bacteria