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Nephrotoxicity Associated with Combined Gentamicin – Amphotericin B Therapy

Nephrotoxicity Associated with Combined Gentamicin – Amphotericin B Therapy The administration of a low total dose of amphotericin B to four consecutive patients already receiving gentamicin resulted in a deterioration of renal function in all. No other cause of the renal dysfunction was apparent in three cases. It appears probable that these drugs exhibit synergistic nephrotoxicity. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nephron Karger

Nephrotoxicity Associated with Combined Gentamicin – Amphotericin B Therapy

Churchill, D.N.; Seely, J.
Nephron , Volume 19 (3): 6 – Jan 1, 1977
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Publisher
Karger
Copyright
© 1977 S. Karger AG, Basel
ISSN
1660-8151
eISSN
2235-3186
DOI
10.1159/000180883
Publisher site
See Article on Publisher Site

Abstract

The administration of a low total dose of amphotericin B to four consecutive patients already receiving gentamicin resulted in a deterioration of renal function in all. No other cause of the renal dysfunction was apparent in three cases. It appears probable that these drugs exhibit synergistic nephrotoxicity.

Journal

Nephron – Karger

Published: Jan 1, 1977

Keywords: Gentamicin; Amphotericin B; Nephrotoxicity

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