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References (23)
-
Xiaoyue Chen, Qin Yan, Shuangdi Li, Long Zhou, Hua-jing Yang, Yi-xia Yang, Xuelian Liu, X. Wan (2012)
Expression of the tumor suppressor miR-206 is associated with cellular proliferative inhibition and impairs invasion in ERα-positive endometrioid adenocarcinoma.Cancer letters, 314 1
-
B. Dey, J. Gagan, Anindya Dutta (2011)
miR-206 and -486 Induce Myoblast Differentiation by Downregulating Pax7Molecular and Cellular Biology, 31
-
L. Bally-Cuif, M. Gulisano, V. Broccoli, E. Boncinelli (1995)
c-otx2 is expressed in two different phases of gastrulation and is sensitive to retinoic acid treatment in chick embryoMechanisms of Development, 49
-
P. Mercier, Antonio Simeone, Franco Cotelli, Edoardo Boncinelli (1995)
Expression pattern of two otx genes suggests a role in specifying anterior body structures in zebrafish.The International journal of developmental biology, 39 4
-
(1994)
Positive and negative signals from mesoderm regulate the expression of mouse Otx 2 in ectoderm explants -
D. Bartel (2009)
MicroRNAs: Target Recognition and Regulatory FunctionsCell, 136
-
C. Di, S. Liao, D. Adamson, T. Parrett, D. Broderick, Qun Shi, C. Lengauer, Jordan Cummins, V. Velculescu, D. Fults, R. McLendon, D. Bigner, Hai Yan (2005)
Identification of OTX2 as a medulloblastoma oncogene whose product can be targeted by all-trans retinoic acid.Cancer research, 65 3
-
M. Rhinn, A. Dierich, M. Meur, S. Ang (1999)
Cell autonomous and non-cell autonomous functions of Otx2 in patterning the rostral brain.Development, 126 19
-
Lin Gan, Chai Mao, A. Wikramanayake, L. Angerer, R. Angerer, William Klein (1995)
An orthodenticle-related protein from Strongylocentrotus purpuratus.Developmental biology, 167 2
-
S. Ang, Ronald Conlon, Ou Jin, Janet Rossant (1994)
Positive and negative signals from mesoderm regulate the expression of mouse Otx2 in ectoderm explants.Development, 120 10
-
RESEARCH ARTICLE Open Access Expression of miR-1, miR-133a, miR-133b and -
Yong Zhao, D. Srivastava (2007)
A developmental view of microRNA function.Trends in biochemical sciences, 32 4
-
Yi Cui, Zhongji Han, Yi Hu, Ge Song, C. Hao, Hongfei Xia, Xu Ma (2012)
MicroRNA‐181b and microRNA‐9 mediate arsenic‐induced angiogenesis via NRP1Journal of Cellular Physiology, 227
-
R. Ibad, J. Rheey, S. Mrejen, V. Forster, S. Picaud, A. Prochiantz, K. Moya (2011)
Otx2 Promotes the Survival of Damaged Adult Retinal Ganglion Cells and Protects against Excitotoxic Loss of Visual Acuity In VivoThe Journal of Neuroscience, 31
-
(2005)
Identification of OTX 2 as a medulloblastoma oncogene whose product can be targeted by all - trans retinoic acid -
J. Martínez-Barbera, M. Signore, P. Boyl, E. Puelles, D. Acampora, R. Gogoi, F. Schubert, A. Lumsden, A. Simeone (2001)
Regionalisation of anterior neuroectoderm and its competence in responding to forebrain and midbrain inducing activities depend on mutual antagonism between OTX2 and GBX2.Development, 128 23
-
Yi Cui, Zhongji Han, Yi Hu, Ge Song, C. Hao, Hongfei Xia, Maiyu Xu (2011)
Q 1 MicroRNA-181 b and microRNA-9 Mediate Arsenic-Induced Angiogenesis via NRP 1 -
J. Li, A. Joyner (2001)
Otx2 and Gbx2 are required for refinement and not induction of mid-hindbrain gene expression.Development, 128 24
-
M. Pannese, C. Polo, M. Andreazzoli, R. Vignali, Boris Kablar, G. Barsacchi, E. Boncinelli (1995)
The Xenopus homologue of Otx2 is a maternal homeobox gene that demarcates and specifies anterior body regions.Development, 121 3
-
T. Rosenquist, S. Ratashak, J. Selhub (1996)
Homocysteine induces congenital defects of the heart and neural tube: effect of folic acid.Proceedings of the National Academy of Sciences of the United States of America, 93 26
-
M. Rhinn, A. Dierich, W. Shawlot, Richard Behringer, M. Meur, S. Ang (1998)
Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification.Development, 125 5
-
A. Simeone, D. Acampora, A. Mallamaci, A. Stornaiuolo, M. D’Apice, Vincenzo Nigro, E. Boncinelli (1993)
A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo.The EMBO Journal, 12
-
V. Hamburger, H. Hamilton (1951)
A series of normal stages in the development of the chick embryoDevelopmental Dynamics, 195
- Publisher
- Karger
- Copyright
- © 2012 S. Karger AG, Basel
- ISSN
- 1015-8987
- eISSN
- 1421-9778
- DOI
- 10.1159/000338493
- Publisher site
- See Article on Publisher Site
Abstract
MiR-206 was involved in a series of cellular activities, such as the growth and development of skeletal muscle and the tumorigenesis. MiR-206 was characterized previously as a differentially expressed gene in sodium arsenite (SA)-induced neural tube defects (NTDs) in chick embryos via miRNA microarray analysis. However, the role of miR-206 in the pathological process of nerve cells remained elusive. In this study we found differential expression of miR-206 in SA-treated chick embryos by Northern blot analysis. Ectopic expression of miR-206inhibited cell proliferation, and promoted cell apoptosis in U343 and SK-N-SH cell by using MTT, Edu Apollo assay and Flow cytometry analysis. Further investigation revealed that miR-206 can interact with 3′-untranslated region (UTR) of Otx2. MiR-206 mimics down-regulated the endogeneous Otx2 expression, whereas the miR-206 inhibitor obviously up-regulated the expression of Otx2. These findings indicate that overexpression of miR-206 promotes cell apoptosis and low expression of miR-206 inhibits cell apoptosis. Otx2 may play an important role in the process of miR-206-mediated cell apoptosis.
Journal
Cellular Physiology and Biochemistry – Karger
Published: Jan 1, 2012
Keywords: miR -206; Human Glioma Cells; Apoptosis; Otx2