Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/karger/karyotype-analysis-and-marker-chromosomes-of-renal-cell-carcinoma-L3DK6DLi0b
References
References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.
- Publisher
- Karger
- Copyright
- © 1988 S. Karger AG, Basel
- ISSN
- 0302-2838
- eISSN
- 1873-7560
- DOI
- 10.1159/000472992
- Publisher site
- See Article on Publisher Site
Abstract
Karyotyping was performed in 46 human renal cell carcinomas of various histological grades. Controlsincluded chromosome analysis of normal renal parenchymal cells from the same patients. Various numerical chromosomeaberrations were found as well as marker chromosomes. They are specific of the individual tumor but nosingle marker was identified occurring in all tumors tested. Only trisomy 3 was found in different tumors (31%),suggesting a more general character of this aberration. Histological dedifferentiation and large tumor size correlatewith focusing of the karyotype towards distinct chromosomal modes indicative of distinct tumor cell subcloneswithin these tumors. Their rapid growth, reflecting biological agressiveness, is most probably responsible for thepatients’ poor prognosis.
Journal
European Urology – Karger
Published: Jan 1, 2017
Keywords: Renal cell carcinoma; Marker chromosomes; Karyotyping