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Jejunal and Heal Glucose-Stimulated Water and Sodium Absorption in Tropical Enteropathy: Implications for Oral Rehydration Therapy

Jejunal and Heal Glucose-Stimulated Water and Sodium Absorption in Tropical Enteropathy:... Intestinal glucose and water absorption in response to glucose has been studied in tropical enteropathy with a view to determine the optimum glucose concentration in oral rehydration solutions for use in the tropics. Maximum jejunal water and sodium absorption occurred from an 80-mM glucose-sodium chloride solution (-285.7 ± 46.0 ml/30 cm/h and -31.8 ± 3.8 mM/30 cm/h, respectively) during in vivo steady-state jejunal perfusion. At perfusate glucose concentrations > 250 mM, however, jejunal water and sodium secretion occurred. In the ileum, maximum glucose-stimulated water absorption (-91.1 ± 27.1 ml/30 cm/h) was significantly less than in the jejunum. Glucose absorption demonstrated saturation kinetics in both the jejunum and ileum. The half-saturation concentration was higher in the jejunum (167 mM) compared to the ileum (28 mM). This study suggests that the optimal glucose concentration for oral rehydration solutions used in the tropics should be 80 mM, as lower and higher concentrations result in diminished jejunal water absorption. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Digestion Karger

Jejunal and Heal Glucose-Stimulated Water and Sodium Absorption in Tropical Enteropathy: Implications for Oral Rehydration Therapy

Rolston, D.D.K.; Mathan, V.I.
Digestion , Volume 46 (1): 6 – Jan 1, 1990
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Publisher
Karger
Copyright
© 1990 S. Karger AG, Basel
ISSN
0012-2823
eISSN
1421-9867
DOI
10.1159/000200278
Publisher site
See Article on Publisher Site

Abstract

Intestinal glucose and water absorption in response to glucose has been studied in tropical enteropathy with a view to determine the optimum glucose concentration in oral rehydration solutions for use in the tropics. Maximum jejunal water and sodium absorption occurred from an 80-mM glucose-sodium chloride solution (-285.7 ± 46.0 ml/30 cm/h and -31.8 ± 3.8 mM/30 cm/h, respectively) during in vivo steady-state jejunal perfusion. At perfusate glucose concentrations > 250 mM, however, jejunal water and sodium secretion occurred. In the ileum, maximum glucose-stimulated water absorption (-91.1 ± 27.1 ml/30 cm/h) was significantly less than in the jejunum. Glucose absorption demonstrated saturation kinetics in both the jejunum and ileum. The half-saturation concentration was higher in the jejunum (167 mM) compared to the ileum (28 mM). This study suggests that the optimal glucose concentration for oral rehydration solutions used in the tropics should be 80 mM, as lower and higher concentrations result in diminished jejunal water absorption.

Journal

Digestion – Karger

Published: Jan 1, 1990

Keywords: Jejunal, ileal absorption; Tropical enteropathy; Oral rehydration therapy

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