Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Interim Analyses in Clinical Trials

Interim Analyses in Clinical Trials The main purpose of performing interim analyses in a clinical trial is to stop the trial once a convincing treatment difference can be demonstrated. The major problem with repeated significance tests during inclusion and/or follow-up in a clinical trial is that the more often one analyses accumulating data, the greater the probability of obtaining a statistically significant result even when there is in reality no treatment difference. To allow for repeated testing, one must therefore choose a more stringent nominal significance level as a criterion for stopping the trial. This paper presents two simple strategies for undertaking interim analyses. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Heart Drug Karger

Interim Analyses in Clinical Trials

Heart Drug , Volume 3 (2): 4 – Apr 1, 2003

Loading next page...
 
/lp/karger/interim-analyses-in-clinical-trials-cdKyhD1MaS

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
Karger
Copyright
© 2003 S. Karger AG, Basel
ISSN
1422-9528
eISSN
1424-0556
DOI
10.1159/000071995
Publisher site
See Article on Publisher Site

Abstract

The main purpose of performing interim analyses in a clinical trial is to stop the trial once a convincing treatment difference can be demonstrated. The major problem with repeated significance tests during inclusion and/or follow-up in a clinical trial is that the more often one analyses accumulating data, the greater the probability of obtaining a statistically significant result even when there is in reality no treatment difference. To allow for repeated testing, one must therefore choose a more stringent nominal significance level as a criterion for stopping the trial. This paper presents two simple strategies for undertaking interim analyses.

Journal

Heart DrugKarger

Published: Apr 1, 2003

Keywords: p value; Interim analysis; Group sequential method; Repeated significance test

There are no references for this article.